New visions for atopic eczema: An iPAC summary and future trends

Authors


  • Conflict of interest: All authors declare no conflict of interests.

Fabienne Rancé, Allergologie – Pneumologie, Hôpital des Enfants, 330 avenue de Grande Bretagne, 31026 Toulouse cedex, France
Tel.: + 33 (0) 5 34 55 85 86
Fax: + 33 (0) 5 34 55 85 89
E-mail: rance.f@chu-toulouse.fr

Abstract

Atopic eczema (AE) is a chronic inflammatory skin disease characterized by pruritus, dry skin and an ongoing course of exacerbations and remissions. AE is a common disorder in children with a worldwide cumulative prevalence of 15–20% in this age group. AE has a strong familial predisposition. While AE is a complex disease with multiple gene involvement, recent interest has focused on genes involved in skin barrier/epidermal differentiation and in immune response/host defense. Recent developments and future directions on pathogenesis, diagnosis, natural course and prognosis are discussed.

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