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Oral desensitization to milk: how to choose the starting dose!
Article first published online: 13 JUL 2009
© 2009 John Wiley & Sons A/S
Pediatric Allergy and Immunology
Volume 21, Issue 2p2, pages e450–e453, March 2010
How to Cite
Mori, F., Pucci, N., Rossi, M. E., De Martino, M., Azzari, C. and Novembre, E. (2010), Oral desensitization to milk: how to choose the starting dose!. Pediatric Allergy and Immunology, 21: e450–e453. doi: 10.1111/j.1399-3038.2009.00917.x
- Issue published online: 26 MAR 2010
- Article first published online: 13 JUL 2009
- Accepted 17 April 2009
- children food allergy;
- end point skin prick test;
- milk allergy;
- oral desensitization
Mori F, Pucci N, Rossi ME, de Martino M, Azzari C, Novembre E. Oral desensitization to milk: how to choose the starting dose! Pediatr Allergy Immunol 2010: 21: e450–e453. © 2009 John Wiley & Sons A/S
A renewed interest in oral desensitization as treatment for food allergy has been observed in the last few years. We studied a novel method based on the end point skin prick test procedure to establish the starting dose for oral desensitization in a group of 30 children higly allergic to milk. The results (in terms of reactions to the first dose administered) were compared with a group of 20 children allergic to milk as well. Such control group started to swallow the same dose of 0.015 mg/ml of milk. None reacted to the first dose when administered according to the end point skin prick test. On the other side, ten out of 20 children (50%) from the control group showed mild allergic reactions to the first dose of milk. In conclusion the end point skin prick test procedure results safe and easy to be performed in each single child in order to find out the starting dose for oral desensitization to milk, also by taking into account the individual variability.