Increased serum thymic stromal lymphopoietin in children with atopic dermatitis

Authors

  • Eun Byoul Lee,

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    • *

      These authors contributed equally to this work.

  • Kyung Won Kim,

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    • *

      These authors contributed equally to this work.

  • Jung Yeon Hong,

    1. Department of Pediatrics and Institute of Allergy, BK21 Project for Medical Science, Research Center for Human Natural Defense System, Yonsei University College of Medicine, Seoul, Korea
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  • Hye Mi Jee,

    1. Department of Pediatrics and Institute of Allergy, BK21 Project for Medical Science, Research Center for Human Natural Defense System, Yonsei University College of Medicine, Seoul, Korea
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  • Myung Hyun Sohn,

    1. Department of Pediatrics and Institute of Allergy, BK21 Project for Medical Science, Research Center for Human Natural Defense System, Yonsei University College of Medicine, Seoul, Korea
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  • Kyu-Earn Kim

    1. Department of Pediatrics and Institute of Allergy, BK21 Project for Medical Science, Research Center for Human Natural Defense System, Yonsei University College of Medicine, Seoul, Korea
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Myung Hyun Sohn, Department of Pediatrics and Institute of Allergy, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul 120-752, Korea.
Tel.: 82 2 2228 2062
Fax: 82 2 393 9118
E-mail: mhsohn@yuhs.ac

Abstract

Lee EB, Kim KW, Hong JY, Jee HM, Sohn MH, Kim K-E. Increased serum thymic stromal lymphopoietin in children with atopic dermatitis.
Pediatr Allergy Immunol 2010: 21: e457–e460.
© 2010 John Wiley & Sons A/S

The present study investigated the relationship between serum thymic stromal lymphopoietin (TSLP) levels and the presence and severity of atopic dermatitis (AD). Serum TSLP levels, blood eosinophil counts, and serum total and specific immunoglobulin E (IgE) levels were measured in 232 children. Subjects were characterized as having atopic eczema (AE; n = 75), non-atopic eczema (NAE; n = 70), or normal controls (n = 87). Serum TSLP levels in children with AD were significantly higher than normal controls but there were no differences in children with atopic and non-atopic eczema. However, serum TSLP levels in children with AD were not significantly correlated with disease severity, blood eosinophil counts and serum total IgE levels. Our findings show an association between TSLP and AD including both AE and NAE. It is suggested that TSLP may play a contributory role in the pathogenesis of AD regardless of the presence of atopy.

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