Specific oral tolerance induction (SOTI) in pediatric age: Clinical research or just routine practice?
Article first published online: 2 JUL 2009
© 2009 John Wiley & Sons A/S
Pediatric Allergy and Immunology
Volume 21, Issue 2p2, pages e446–e449, March 2010
How to Cite
Sopo, S. M., Onesimo, R., Giorgio, V. and Fundarò, C. (2010), Specific oral tolerance induction (SOTI) in pediatric age: Clinical research or just routine practice?. Pediatric Allergy and Immunology, 21: e446–e449. doi: 10.1111/j.1399-3038.2009.00922.x
- Issue published online: 26 MAR 2010
- Article first published online: 2 JUL 2009
- Accepted 2 June 2009
- specific oral tolerance induction;
- food allergy;
Miceli Sopo S, Onesimo R, Giorgio V, Fundarò C. Specific oral tolerance induction (SOTI) in pediatric age: Clinical research or just routine practice? Pediatr Allergy Immunol 2010: 21: e446–e449. © 2009 John Wiley & Sons A/S
Specific Oral Tolerance (SOTI) is a promising therapy of food allergy, specially for IgE-mediated cow milk allergy (CMA) in pediatric age. Randomized controlled trials have reported that about 35% of children, at least 5 years of age, became full tolerant to cow milk proteins after SOTI. Regard to the safety, literature describes about 200 children who underwent SOTI, with no fatal events. Nevertheless, a considerable percentage of those children (15%–20%) had to stop SOTI, because of important adverse effects. Numerous protocols have been described, some audacious and other prudent, however all demand an intense commitment either of the doctors and of the families. The information about the follow up of the children who underwent SOTI are still insufficient. For these reasons, we think that SOTI is still an experimental therapy.