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Effect of probiotic mix (Bifidobacterium bifidum, Bifidobacterium lactis, Lactobacillus acidophilus) in the primary prevention of eczema: a double-blind, randomized, placebo-controlled trial

Authors

  • Ji Yeun Kim,

    1. Department of Food and Nutrition, College of Human Ecology, Seoul National University, San 56-1, Shinlimdong, Kwanakku, Seoul, Korea
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  • Jung Hyun Kwon,

    1. Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Cheoncheondong, Jangangu, Suwon, Gyeonggido, Korea
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  • So Hyun Ahn,

    1. Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Cheoncheondong, Jangangu, Suwon, Gyeonggido, Korea
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  • Sang Il Lee,

    1. Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Cheoncheondong, Jangangu, Suwon, Gyeonggido, Korea
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  • Young Shin Han,

    1. Department of Pediatrics, Samsung Medical Center, 50 Irwon-dong, Gangnam-gu, Seoul, Korea
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  • Young Ok Choi,

    1. Department of Food and Nutrition, College of Human Ecology, Seoul National University, San 56-1, Shinlimdong, Kwanakku, Seoul, Korea
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  • Soo Young Lee,

    1. Department of Pediatrics, Ajou University School of Medicine, San 5, Woncheondong, Youngtonggu, Suwon, Gyeonggido, Korea
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  • Kang Mo Ahn,

    1. Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Cheoncheondong, Jangangu, Suwon, Gyeonggido, Korea
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    • *

      They contributed to correspondence authors equally to this work.

  • Geun Eog Ji

    1. Department of Food and Nutrition, College of Human Ecology, Seoul National University, San 56-1, Shinlimdong, Kwanakku, Seoul, Korea
    2. Research Institute, Bifido Inc. 688-1, Hongcheongun, Kangwondo, Korea
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    • *

      They contributed to correspondence authors equally to this work.


Geun Eog Ji, Department of Food and Nutrition, College of Human Ecology, Seoul National University, San 56-1, Shinlimdong, Kwanakku, Seoul 152-742, Korea
Tel.: +82 2 880 8749, +82 11 729 8672
Fax: +82 2 884 0305
E-mail: geji@snu.ac.kr

Abstract

Kim JY, Kwon JH, Ahn SH, Lee SI, Han YS, Choi YO, Lee SY, Ahn KM, Ji GE. Effect of probiotic mix (Bifidobacterium bifidum, Bifidobacterium lactis, Lactobacillus acidophilus) in the primary prevention of eczema: a double-blind, randomized, placebo-controlled trial.
Pediatr Allergy Immunol 2010: 21: e386–e393.
© 2009 John Wiley & Sons A/S

Controversy exists regarding the preventive effect of probiotics on the development of eczema or atopic dermatitis. We investigated whether supplementation of probiotics prevents the development of eczema in infants at high risk. In a randomized, double-blind, placebo-controlled trial, 112 pregnant women with a family history of allergic diseases received a once-daily supplement, either a mixture of Bifidobacterium bifidum BGN4, B. lactis AD011, and Lactobacillus acidophilus AD031, or placebo, starting at 4–8 wks before delivery and continuing until 6 months after delivery. Infants were exclusively breast-fed during the first 3 months, and were subsequently fed with breastmilk or cow’s milk formula from 4 to 6 months of age. Clinical symptoms of the infants were monitored until 1 yr of age, when the total and specific IgE against common food allergens were measured. A total of 68 infants completed the study. The prevalence of eczema at 1 yr in the probiotic group was significantly lower than in the placebo group (18.2% vs. 40.0%, p = 0.048). The cumulative incidence of eczema during the first 12 months was reduced significantly in probiotic group (36.4% vs. 62.9%, p = 0.029); however, there was no difference in serum total IgE level or the sensitization against food allergens between the two groups. Prenatal and postnatal supplementation with a mixture of B. bifidum BGN4, B. lactis AD011, and L. acidophilus AD031 is an effective approach in preventing the development of eczema in infants at high risk of allergy during the first year of life.

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