Haplotypes covering the TNFSF10 gene are associated with bronchial asthma
Version of Record online: 20 OCT 2010
© 2010 John Wiley & Sons A/S
Pediatric Allergy and Immunology
Volume 22, Issue 1-Part-I, pages 25–30, February 2011
How to Cite
Weckmann, M., Kopp, M. V., Heinzmann, A. and Mattes, J. (2011), Haplotypes covering the TNFSF10 gene are associated with bronchial asthma. Pediatric Allergy and Immunology, 22: 25–30. doi: 10.1111/j.1399-3038.2010.01027.x
- Issue online: 24 JAN 2011
- Version of Record online: 20 OCT 2010
- Accepted for publication 20 February 2010
To cite this article: Weckmann M, Kopp MV, Heinzmann A, Mattes J. Haplotypes covering the TNFSF10 gene are associated with bronchial asthma. Pediatric Allergy Immunology 2011: 22: 25–30.
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is elevated in the airways of subjects with asthma and has been linked to the development of allergic airway disease by promoting STAT6-dependent T helper 2 cell (TH2) effector functions. To determine whether single nucleotide polymorphisms (SNPs) in the TNFSF10 gene are associated with bronchial asthma we genotyped 498 Caucasian subjects living in Southern Germany for eight SNPs in the TNFSF10 by restriction fragment length polymorphism analysis. In contrast to single SNPs, haplotypes constructed from eight SNPs were robustly associated with asthma (p = 0.00012). A small haplotype approach returned four alleles consisting of two (rs3136586/ rs3136598), three (rs12488654/rs3136586/rs3136598 and rs3136586/rs3136598/rs3136604), and four SNPs (rs12488654/ rs3136586/ rs3136598/ rs3136604) that were highly associated with asthma (p = 0.00005, p = 0.00008, p = 0.00017 and p = 0.00038). Combinations of SNPs in the TNFSF10 allele were strongly associated with asthma supporting the concept that TRAIL is important in the development of hallmark features of this disease.