Supported by the Academy of Finland, the Finnish Cultural Foundation, the Turku University Foundation, the Foundation for Pediatric Research, and the Foundation for Out-Patient Research.
Allergic sensitization is associated with rhinovirus-, but not other virus-, induced wheezing in children
Article first published online: 26 OCT 2010
© 2010 John Wiley & Sons A/S
Pediatric Allergy and Immunology
Volume 21, Issue 7, pages 1008–1014, November 2010
How to Cite
Jartti, T., Kuusipalo, H., Vuorinen, T., Söderlund-Venermo, M., Allander, T., Waris, M., Hartiala, J. and Ruuskanen, O. (2010), Allergic sensitization is associated with rhinovirus-, but not other virus-, induced wheezing in children. Pediatric Allergy and Immunology, 21: 1008–1014. doi: 10.1111/j.1399-3038.2010.01059.x
- Issue published online: 26 OCT 2010
- Article first published online: 26 OCT 2010
- Accepted 15 March 2010
- respiratory syncytial virus;
Jartti T, Kuusipalo H, Vuorinen T, Söderlund-Venermo M, Allander T, Waris M, Hartiala J, Ruuskanen O. Allergic sensitization is associated with rhinovirus-, but not other virus-, induced wheezing in children. Pediatr Allergy Immunol 2010: 21: 1008–1014. © 2010 John Wiley & Sons A/S
Background: Data on the link between atopy and viral wheeze are limited. Aim: To evaluate the association between IgE sensitization and viral infection in wheezing children. Methods: This is an observational study in hospitalized wheezing children (n = 247; median age 1.6 ; interquartile range 1.1, 2.9). Eighteen respiratory viral infections were studied using all available methods. A specific immunoglobulin E (IgE) sensitization for common food and aeroallergens and other atopy-related variables including total IgE, blood and nasal eosinophils, exhaled nitric oxide, eczema and atopic eczema, parental allergy and asthma, number of wheezing episodes, positive asthma predictive index or asthma and use of inhaled corticosteroid were correlated with specific viral etiology. Results: Atopy was closely associated with sole rhinovirus etiology (n = 58) but not with sole respiratory syncytial virus, sole enterovirus, sole human bocavirus, sole other virus, mixed viral, or virus negative etiology. The number of sensitizations was particularly associated with sole rhinovirus etiology (odds ratio 4.59; 95% confidence interval 1.78, 11.8; adjusted to age and sex), followed by aeroallergen sensitization (respectively; 4.18; 2.00, 8.72), total IgE level (2.06; 1.32, 3.21), food allergen sensitization (2.02; 1.08, 3.78), and nasal eosinophil count (1.52; 1.08, 2.13). Conclusions: According to our data, allergic sensitization is positively linked to rhinovirus-, but not other virus-, associated wheezing and calls attention for studies to test rhinovirus-associated wheezing as a part of asthma risk indices.