Allergic diseases among very preterm infants according to nutrition after hospital discharge
Version of Record online: 20 FEB 2011
© 2011 John Wiley & Sons A/S
Pediatric Allergy and Immunology
Volume 22, Issue 5, pages 515–520, August 2011
How to Cite
Zachariassen, G., Faerk, J., Esberg, B. H., Fenger-Gron, J., Mortensen, S., Christesen, H. T. and Halken, S. (2011), Allergic diseases among very preterm infants according to nutrition after hospital discharge. Pediatric Allergy and Immunology, 22: 515–520. doi: 10.1111/j.1399-3038.2010.01102.x
- Issue online: 19 JUL 2011
- Version of Record online: 20 FEB 2011
- Accepted for publication 1 September 2010
- mother’s milk;
- human milk fortifier;
- preterm infants;
- allergic disease
To cite this article: Zachariassen G, Faerk J, Esberg BH, Fenger-Gron J, Mortensen S, Christesen HT, Halken S. Allergic diseases among very preterm infants according to nutrition after hospital discharge. Pediatr Allergy Immunol 2011; 22: 515–520.
To determine whether a cow’s milk-based human milk fortifier (HMF) added to mother’s milk while breastfeeding or a cow’s milk-based preterm formula compared to exclusively mother’s milk after hospital discharge, increases the incidence of developing allergic diseases among very preterm infants (VPI) during the first year of life.
Of a cohort of 324 VPI (gestational age 24–32 wk), the exclusively breastfed VPI were shortly before discharge randomized to breastfeeding without fortification or supplementing with a fortifier. Those not breastfed were fed a preterm formula. The intervention period was from discharge until 4 months corrected age (CA). Follow-up was performed at 4 and 12 months CA including specific IgE to a panel of allergens at 4 months CA.
The incidence during and prevalence at 12 months CA of recurrent wheezing (RW) was 39.2% and 32.7%, while atopic dermatitis (AD) was 18.0% and 12.1%, respectively. Predisposition to allergic disease increased the risk of developing AD (p = 0.04) [OR 2.6 (95% CI 1.0–6.4)] and the risk of developing RW (p = 0.02) [OR 2.7 (95% CI 1.2–6.3)]. Boys had an increased risk of developing RW (p = 0.003) [OR 3.1 (95% CI 1.5–6.5)]. No difference was found between nutrition groups. None developed food allergy.
Compared to exclusively breastfed, VPI supplemented with HMF or fed exclusively a preterm formula for 4 months did not have an increased risk of developing allergic diseases during the first year of life.