Current address: Division of Immunology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02445, USA.
Clinical characteristics of pediatric patients evaluated for primary immunodeficiency
Article first published online: 30 MAR 2011
© 2011 John Wiley & Sons A/S
Pediatric Allergy and Immunology
Volume 22, Issue 7, pages 671–675, November 2011
How to Cite
MacGinnitie, A., Aloi, F. and Mishra, S. (2011), Clinical characteristics of pediatric patients evaluated for primary immunodeficiency. Pediatric Allergy and Immunology, 22: 671–675. doi: 10.1111/j.1399-3038.2011.01167.x
- Issue published online: 22 SEP 2011
- Article first published online: 30 MAR 2011
- Accepted for publication 17 February 2011
- common variable immunodeficiency;
- intravenous immunoglobulin;
- primary immunodeficiency
To cite this article: MacGinnitie A, Aloi F, Mishra S. Clinical characteristics of pediatric patients evaluated for primary immunodeficiency. Pediatric Allergy Immunology 2011; 22: 671–675.
Objective: When to evaluate a child for possible immune deficiency is a challenge, as many children have frequent infections for which they are treated with antibiotics. We aimed to describe the clinical characteristics of children evaluated for possible primary immunodeficiency in a specialist clinic. We specifically aimed to evaluate widely promulgated ‘warning signs of primary immunodeficiency’ and to evaluate the relationship between primary immunodeficiency and atopy.
Methods: A retrospective analysis of 141 children who underwent testing for possible primary immunodeficiency was undertaken.
Results: Thirty-two (23%) children were diagnosed with an underlying primary immunodeficiency, and published warning signs were neither sensitive nor specific for primary immunodeficiency. Patients with allergy as determined by the presence of antigen-specific IgE were more likely to be diagnosed with immunodeficiency.
Conclusions: Widely promulgated warning signs did not distinguish between patients with and without primary immunodeficiency. Likewise, primary immunodeficiency and allergy may coexist.