Phadiatop Infant® detects IgE-mediated diseases among pre-school children: a prospective study
Article first published online: 19 SEP 2011
© 2011 John Wiley & Sons A/S
Pediatric Allergy and Immunology
Volume 23, Issue 2, pages 160–166, March 2012
How to Cite
Nilsson, C., Lilja, G., Nordlund, M., Berthold, M. and Borres, M. P. (2012), Phadiatop Infant® detects IgE-mediated diseases among pre-school children: a prospective study. Pediatric Allergy and Immunology, 23: 160–166. doi: 10.1111/j.1399-3038.2011.01203.x
- Issue published online: 21 MAR 2012
- Article first published online: 19 SEP 2011
- Accepted for publication 7 July 2011
- Phadiatop Infant;
To cite this article: Nilsson C, Lilja L, Nordlund M, Berthold M, Borres MP. Phadiatop Infant® detects IgE-mediated diseases among pre-school children: a prospective study. Pediatr Allergy Immunol 2011; Doi: 10.1111/j.1399-3038.2011.01203.x
Background: IgE-sensitization to food and inhalant allergens may precede and accompany the appearance of clinical symptoms of allergic diseases. The aim was to study the diagnostic capacity of Phadiatop® Infant (Phinf) for detecting IgE-sensitization at 5 yr of age and further to evaluate the predictive capacity of Phinf longitudinally with regard to sensitization and allergic symptoms in pre-school children.
Methods: Two hundred and one children with complete data on sIgE testing for 10 individual allergens, Phinf analyses, and clinical evaluations at 2 and 5 yr of age were evaluated.
Results: The diagnostic performance of Phinf, applied at the age of 5 and compared to specific IgE testing, gave a sensitivity of 84% and a specificity of 98%. The positive and negative predictive values were 97% and 92%, respectively. A positive Phinf test at 2 yr increased the odds 35.6-fold (95% CI 11.8–107) for IgE-sensitization and 14.7-fold (95% CI 4.4–49.7) for any allergic symptom at 5 yr of age. The association (OR) between Phinf and current symptoms was, at 2 and 5 yr of age, 3.6 (95% CI 1.6–7.9) and 18.4 (95% CI 7.4–45.8), respectively.
Conclusions: Phinf seems to be a reliable tool for predicting future sensitization as well as allergic symptoms in young children.