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ORIGINAL ARTICLE

Phadiatop Infant® detects IgE-mediated diseases among pre-school children: a prospective study

  1. Caroline Nilsson1,
  2. Gunnar Lilja1,
  3. Monica Nordlund1,
  4. Malin Berthold2,
  5. Magnus P. Borres3,4

Article first published online: 19 SEP 2011

DOI: 10.1111/j.1399-3038.2011.01203.x

Issue

Pediatric Allergy and Immunology

Pediatric Allergy and Immunology

Volume 23, Issue 2, pages 160–166, March 2012

Additional Information

How to Cite

Nilsson, C., Lilja, G., Nordlund, M., Berthold, M. and Borres, M. P. (2012), Phadiatop Infant® detects IgE-mediated diseases among pre-school children: a prospective study. Pediatric Allergy and Immunology, 23: 160–166. doi: 10.1111/j.1399-3038.2011.01203.x

Author Information

  1. 1

    Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet and Sachs’ Children’s Hospital, Stockholm, Sweden

  2. 2

    Meira Life Science AB, Stockholm, Sweden

  3. 3

    Scientific Affairs Allergy & Asthma, Phadia AB, Uppsala, Sweden

  4. 4

    Depaertment of Pediatrics, Institution of Maternal and Child Health, Sahlgrenska Academy at Göteborg University, Göteborg, Sweden

*Caroline Nilsson MD, Ph.D., Sachs’ Children’s Hospital, S-118 83 Stockholm, Sweden. Tel.: +46 8 616 4062 Fax: +46 8 616 4007 E-mail: caroline.nilsson@sodersjukhuset.se

Publication History

  1. Issue published online: 21 MAR 2012
  2. Article first published online: 19 SEP 2011
  3. Accepted for publication 7 July 2011

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Keywords:

  • atopy;
  • children;
  • IgE;
  • Phadiatop Infant;
  • sensitization

To cite this article: Nilsson C, Lilja L, Nordlund M, Berthold M, Borres MP. Phadiatop Infant® detects IgE-mediated diseases among pre-school children: a prospective study. Pediatr Allergy Immunol 2011; Doi: 10.1111/j.1399-3038.2011.01203.x

Abstract

Background:  IgE-sensitization to food and inhalant allergens may precede and accompany the appearance of clinical symptoms of allergic diseases. The aim was to study the diagnostic capacity of Phadiatop® Infant (Phinf) for detecting IgE-sensitization at 5 yr of age and further to evaluate the predictive capacity of Phinf longitudinally with regard to sensitization and allergic symptoms in pre-school children.

Methods:  Two hundred and one children with complete data on sIgE testing for 10 individual allergens, Phinf analyses, and clinical evaluations at 2 and 5 yr of age were evaluated.

Results:  The diagnostic performance of Phinf, applied at the age of 5 and compared to specific IgE testing, gave a sensitivity of 84% and a specificity of 98%. The positive and negative predictive values were 97% and 92%, respectively. A positive Phinf test at 2 yr increased the odds 35.6-fold (95% CI 11.8–107) for IgE-sensitization and 14.7-fold (95% CI 4.4–49.7) for any allergic symptom at 5 yr of age. The association (OR) between Phinf and current symptoms was, at 2 and 5 yr of age, 3.6 (95% CI 1.6–7.9) and 18.4 (95% CI 7.4–45.8), respectively.

Conclusions:  Phinf seems to be a reliable tool for predicting future sensitization as well as allergic symptoms in young children.

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