Educational case series: β-lactam allergy and cross-reactivity
Article first published online: 19 SEP 2011
© 2011 John Wiley & Sons A/S
Pediatric Allergy and Immunology
Volume 22, Issue 8, pages 770–775, December 2011
How to Cite
Atanasković-Marković, M. (2011), Educational case series: β-lactam allergy and cross-reactivity. Pediatric Allergy and Immunology, 22: 770–775. doi: 10.1111/j.1399-3038.2011.01204.x
- Issue published online: 29 NOV 2011
- Article first published online: 19 SEP 2011
- Accepted for publication 8 July 2011
- β-lactam allergy;
- drug provocation tests;
- in vivo tests;
- in vitro tests;
- immediate allergic reactions;
- non-immediate allergic reactions;
- skin tests
To cite this article: Atanasković-Marković M. Educational case series: β-lactam allergy and cross-reactivity. Pediatr Allergy Immunol 2011: 22: 770–775.
Penicillins and cephalosporins are the most widely used antibiotics for the treatment of common infections, and they are the two main classes of β-lactams. On the basis of the time of appearance of the reaction after drug intake and for diagnostic purposes, hypersensitivity reactions to β-lactams have been classified as immediate or non-immediate. The diagnostic evaluation of allergic reactions to β-lactams has changed over the last decade, for several reasons. In many countries, major and minor determinants for skin testing are not available. In immediate allergic reactions, the sensitivity of skin testing is decreasing. For non-immediate reactions, skin testing appears to be less sensitive than previously reported. The drug provocation test is still necessary for diagnosis.
In this education review series, we described three cases of β-lactam allergy: first, a child with an IgE-mediated allergy to benzyl-penicillin; second, a child with a non-allergic hypersensitivity to amoxicillin; and in the third patient, we will discuss about cross-reactivity between penicillins and cephalosporins. These cases are correlated with the practical management of evaluating β-lactam allergy.