Both authors contributed equally to this work
Comparison of neonatal T regulatory cell function in Papua New Guinean and Australian newborns
Article first published online: 23 DEC 2011
© 2011 John Wiley & Sons A/S
Pediatric Allergy and Immunology
Volume 23, Issue 2, pages 173–180, March 2012
How to Cite
Lisciandro, J. G., Prescott, S. L., Nadal-Sims, M. G., Devitt, C. J., Pomat, W., Siba, P. M., Holt, P. G., Strickland, D. and van den Biggelaar, A. H.J. (2012), Comparison of neonatal T regulatory cell function in Papua New Guinean and Australian newborns. Pediatric Allergy and Immunology, 23: 173–180. doi: 10.1111/j.1399-3038.2011.01242.x
- Issue published online: 21 MAR 2012
- Article first published online: 23 DEC 2011
- Accepted for publication 19 October 2011
- cord blood;
- hygiene hypothesis;
- Papua New Guinea;
- T regulatory cell
To cite this article: Lisciandro JG, Prescott SL, Nadal-Sims MG, Devitt CJ, Pomat W, Siba PM., Holt PG, Strickland D, van den Biggelaar AHJ. Comparison of neonatal T regulatory cell function in Papua New Guinean and Australian newborns. Pediatr Allergy Immunol 2011: Doi: 10.1111/j.1399-3038.2011.01242.x.
Background: Environmental changes, including declining microbial exposure, have been linked with the rising incidence of allergic and autoimmune diseases in ‘western’ populations. This potentially occurs by altering early development of immuno-regulatory pathways including T regulatory cells (Treg). There is now increasing evidence that such conditioning begins in utero.
Methods: We compared neonatal Treg from children born under typical western conditions (Australia, AUS) with those of neonates born under more traditional conditions of high microbial burden (Papua New Guinea, PNG).
Results: The frequency of neonatal Treg, defined as CD4+ Foxp3+ CD127− CD25+/high was found to be higher in the cord blood of AUS compared to PNG newborns. However, cord Treg suppressive function in a small subset of children was qualitatively similar between PNG and AUS newborns in both a Treg depletion assay and a Treg supplementation assay.
Conclusions: These findings do not support the hypothesis that living in a ‘western’ versus more traditional environment leads to poor induction or suppressive function of neonatal Treg. However, environmentally-induced immuno-regulation may potentially occur via alternative mechanisms in PNG newborns that should now be investigated further.