Peanut sensitization during the first 5 yr of life is associated with elevated levels of peanut-specific IgG
Version of Record online: 17 APR 2012
© 2012 John Wiley & Sons A/S
Pediatric Allergy and Immunology
Volume 23, Issue 3, pages 224–229, May 2012
How to Cite
Sverremark-Ekström, E., Hultgren, E. H., Borres, M. P. and Nilsson, C. (2012), Peanut sensitization during the first 5 yr of life is associated with elevated levels of peanut-specific IgG. Pediatric Allergy and Immunology, 23: 224–229. doi: 10.1111/j.1399-3038.2012.01290.x
- Issue online: 17 APR 2012
- Version of Record online: 17 APR 2012
- Accepted for publication 30 January 2012
- Ara h 2;
- Ara h 8;
To cite this article: Sverremark-Ekström E, Hultgren EH, Borres MP, Nilsson C. Peanut sensitization during the first 5 yr of life is associated with elevated levels of peanut-specific IgG. Pediatr Allergy Immunol 2012: 23: 224–229.
Background: Allergen-specific IgE antibodies are implicated in allergic diseases while allergen-specific IgG antibodies have been proposed to prevent allergic reactions. The objective for this study was to study whether the immune response (IgG and IgG4) to peanut differs in IgE-sensitized and non-sensitized young children.
Methods: A total of 239 children have been followed prospectively from birth to 5 yr of age. The levels of IgG and IgG4 to peanut, Ara h 2, and Ara h 8 were analyzed at 2 and 5 yr of age and related to IgE sensitization and peanut consumption.
Results: The levels of peanut-specific IgG and IgG4 were significantly higher in peanut-sensitized children at 2 and 5 yr of age when compared with non-sensitized children and children sensitized to other food/inhalant allergens. A strong correlation was seen between levels of peanut-specific IgG/IgG4-ratios and peanut-specific IgE at 5 yr of age. Children avoiding peanuts, a subgroup of the peanut sensitized, had statistically significant higher levels of IgE to peanut and a tendency of higher IgG and IgG4 levels to peanut. In the avoidance group, significant correlations between IgE and IgG/IgG4 to peanut were found compared with children eating peanuts.
Conclusion: Peanut-specific IgG or IgG4 levels were elevated in peanut-sensitized children especially those avoiding peanuts. In our study, IgG and IgG4 do not seem to indicate tolerance or protection from sensitization.