Unrelated cord blood transplantation in children with sickle cell disease: Review of four-center experience


  • Presented in part at the 47th American Society of Hematology Annual Meeting, Atlanta, 2005.

Thomas V. Adamkiewicz, MD, MsCR, FRCP(C), Assistant Professor, Department of Family Medicine, Division of Research, Morehouse School of Medicine, 1513 East Cleveland Avenue, Building 100, Suite 300-A, East Point, GA 30344, USA
Tel.: +1 404 756 1230
Fax: +1 404 756 1229
E-mail: tadamkiewicz@msm.edu


Abstract:  UCBT was performed in seven children with SCD and stroke (HLA match 4/6 n = 5; 5/6 n = 2). Four received myeloablative regimens (BU, CY, ATG plus FLU in one patient). One had primary graft failure, three had sustained engraftment, two with grade III–IV GVHD (one died, one developed chronic GVHD), one with stable mixed chimerism. Three patients treated with reduced-intensity regimens (FLU, BU or CY, ATG, TLI) failed to engraft; one engrafted after second UCBT (HU, TT, RXA, ALZ, TBI). Four patients (57%) developed viral infections. Engraftment, GVHD, and infection remain challenges.