Presented in part at the 47th American Society of Hematology Annual Meeting, Atlanta, 2005.
Unrelated cord blood transplantation in children with sickle cell disease: Review of four-center experience
Article first published online: 27 JUL 2007
Volume 11, Issue 6, pages 641–644, September 2007
How to Cite
Adamkiewicz, T. V., Szabolcs, P., Haight, A., Baker, K. S., Staba, S., Kedar, A., Chiang, K. Y., Krishnamurti, L., Boyer, M. W., Kurtzberg, J., Wagner, J. E., Wingard, J. R. and Yeager, A. M. (2007), Unrelated cord blood transplantation in children with sickle cell disease: Review of four-center experience. Pediatric Transplantation, 11: 641–644. doi: 10.1111/j.1399-3046.2007.00725.x
- Issue published online: 27 JUL 2007
- Article first published online: 27 JUL 2007
- Accepted for publication 28 February 2007
- sickle cell disease;
- umbilical cord transplant;
- unrelated donor transplant;
- reduced intensity conditioning
Abstract: UCBT was performed in seven children with SCD and stroke (HLA match 4/6 n = 5; 5/6 n = 2). Four received myeloablative regimens (BU, CY, ATG plus FLU in one patient). One had primary graft failure, three had sustained engraftment, two with grade III–IV GVHD (one died, one developed chronic GVHD), one with stable mixed chimerism. Three patients treated with reduced-intensity regimens (FLU, BU or CY, ATG, TLI) failed to engraft; one engrafted after second UCBT (HU, TT, RXA, ALZ, TBI). Four patients (57%) developed viral infections. Engraftment, GVHD, and infection remain challenges.