Outcomes of transplantation in children with primary hepatic malignancy

Authors

  • Mona Beaunoyer,

    1. Divisions of Transplantation, Lucile Salter Packard Children’s Hospital and Stanford University School of Medicine, Stanford, CA, USA
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  • Jason M. Vanatta,

    1. Divisions of Transplantation, Lucile Salter Packard Children’s Hospital and Stanford University School of Medicine, Stanford, CA, USA
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  • Makoto Ogihara,

    1. Divisions of Transplantation, Lucile Salter Packard Children’s Hospital and Stanford University School of Medicine, Stanford, CA, USA
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  • Debra Strichartz,

    1. Divisions of Transplantation, Lucile Salter Packard Children’s Hospital and Stanford University School of Medicine, Stanford, CA, USA
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  • Gary Dahl,

    1. Pediatric Hematology/Oncology, Lucile Salter Packard Children’s Hospital and Stanford University School of Medicine, Stanford, CA, USA
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  • William E. Berquist,

    1. Pediatric Gastroenterology, Hepatology and Nutrition, Lucile Salter Packard Children’s Hospital and Stanford University School of Medicine, Stanford, CA, USA
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  • Ricardo O. Castillo,

    1. Pediatric Gastroenterology, Hepatology and Nutrition, Lucile Salter Packard Children’s Hospital and Stanford University School of Medicine, Stanford, CA, USA
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  • Kenneth L. Cox,

    1. Pediatric Gastroenterology, Hepatology and Nutrition, Lucile Salter Packard Children’s Hospital and Stanford University School of Medicine, Stanford, CA, USA
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  • Carlos O. Esquivel

    1. Divisions of Transplantation, Lucile Salter Packard Children’s Hospital and Stanford University School of Medicine, Stanford, CA, USA
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Carlos O. Esquivel, MD, PhD, The Arnold and Barbara Silverman Professor of Pediatric Transplantation, Professor of Surgery and Chief, Division of Transplantation Stanford University, 750 Welch Rd. Suite 319, Stanford, CA 94304 USA
Tel.: (650) 498-5689
Fax: (650) 498-5690 E-mail: esquivel@stanford.edu

Abstract

Abstract:  HBL and HCC are the most common hepatic malignancies in children. The role of OLT in children with HCC is still a matter of debate. The aim of this study was to review our experience of OLT for HCC. Medical records of patients (< 18 yr) who underwent OLT for HCC were reviewed and compared to children who underwent OLT for HBL and for indications other than malignancy. There were 25 patients: HCC (10 cases) and HBL (15 cases). The actuarial patient survival for HCC at one and five yr was 100% and 83.3%, for the HBL group the survival was 86.7% at both one and five yr, and for indications (n = 377) other than malignancy the patient survival for pediatric OLT at our center was 87.7% and 84.7% at one and five yr, respectively. The actuarial recurrence free survival at five yr was 83.3% for HCC and 66.8% for HBL. In conclusion, OLT is a good therapeutic modality for children with HCC and HBL.

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