Human adipose tissue-derived mesenchymal stromal cells as salvage therapy for treatment of severe refractory acute graft-vs.-host disease in two children

  1. Baijun Fang1,
  2. Yongping Song1,
  3. Quande Lin1,
  4. Yanli Zhang1,
  5. Ying Cao2,
  6. Robert Chunhua Zhao2,
  7. Yuanfang Ma3

Article first published online: 29 AUG 2007

DOI: 10.1111/j.1399-3046.2007.00780.x

Issue

Pediatric Transplantation

Pediatric Transplantation

Volume 11, Issue 7, pages 814–817, November 2007

Additional Information

How to Cite

Fang, B., Song, Y., Lin, Q., Zhang, Y., Cao, Y., Zhao, R. C. and Ma, Y. (2007), Human adipose tissue-derived mesenchymal stromal cells as salvage therapy for treatment of severe refractory acute graft-vs.-host disease in two children. Pediatric Transplantation, 11: 814–817. doi: 10.1111/j.1399-3046.2007.00780.x

Author Information

  1. 1

    Henan Institute of Haematology, Henan Tumor Hospital, Zhengzhou, China

  2. 2

    Center of Excellence in Tissue Engineering, Institute of Basic Medical Sciences and School of Basic Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

  3. 3

    Laboratory of Cellular and Molecular Immunology, Institute of Immunology, Henan University, Kaifeng, China

*Yongping Song, Henan Tumor Hospital, Institute of Haematology, 127 Dongming Road, Zhengzhou 450008, China Tel.: +86-371-65587357 Fax: +86-371-65961505 E-mail: fdation@126.com

Publication History

  1. Issue published online: 29 AUG 2007
  2. Article first published online: 29 AUG 2007
  3. Accepted for publication 14 June 2007

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Keywords:

  • hematopoietic stem cell transplantation;
  • graft-vs.-host disease;
  • mesenchymal stromal cell;
  • adipose tissue

Abstract:  Severe GVHD is a lethal complication to ASCT, and a number of approaches are therefore being evaluated. Recently, Le Blanc et al. reported a case of grade IV therapy-resistant acute GVHD of the gut and liver that showed rapid improvement after infusion of mesenchymal stem cells. Here we describe two pediatric patients who developed severe refractory acute GVHD following ASCT and were successfully treated with AMSC from HLA-mismatched unrelated donors.

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