Unusual case of Epstein–Barr virus DNA tissue positive: Blood negative in a patient with post-transplant lymphoproliferative disorder
Version of Record online: 11 MAY 2008
© 2008 Wiley Periodicals, Inc.
Volume 13, Issue 1, pages 134–138, February 2009
How to Cite
Levenson, B. M., Ali, S. A., Timmons, C. F., Mittal, N., Muthukumar, A. and Payne, D. A. (2009), Unusual case of Epstein–Barr virus DNA tissue positive: Blood negative in a patient with post-transplant lymphoproliferative disorder. Pediatric Transplantation, 13: 134–138. doi: 10.1111/j.1399-3046.2008.00965.x
- Issue online: 6 JAN 2009
- Version of Record online: 11 MAY 2008
- Accepted for publication 26 February 2008
- lymph node;
- peripheral blood
Abstract: Detection of PTLD uses PCR to detect circulating EBV DNA in the blood or in situ hybridization to identify EBV DNA in tissue biopsies. EBV DNA was detected in the tissue section using both real-time PCR and in situ hybridization. We report an unusual presentation of PTLD with no detectable EBV DNA in the blood using EBER-1 and EBNA-1 PCR assays. This report suggests that the use of EBV-PCR for the early detection of PTLD in blood samples may not be 100% effective in detecting disease.