Transmission of clear cell tumor in a graft liver from cadaveric donor: Case report
Version of Record online: 11 MAY 2012
© 2012 John Wiley & Sons A/S
Volume 16, Issue 8, pages E352–E355, December 2012
How to Cite
Backes, A. N., Tannuri, A. C. A., de Mello, E. S., Gibelli, N. E. M., de Castro Andrade, W. and Tannuri, U. (2012), Transmission of clear cell tumor in a graft liver from cadaveric donor: Case report. Pediatric Transplantation, 16: E352–E355. doi: 10.1111/j.1399-3046.2012.01711.x
- Issue online: 7 NOV 2012
- Version of Record online: 11 MAY 2012
- Accepted for publication 19 March 2012
- complications of liver transplantation;
- liver transplantation;
- pediatric liver transplantation;
Backes AN, Tannuri ACA, de Mello ES, Gibelli NEM, de Castro Andrade W, Tannuri U. Transmission of clear cell tumor in a graft liver from cadaveric donor: Case report.
Abstract: Neoplasms in children after organ transplantation are related to the type and intensity of immunosuppression and the donor–recipient serostatus, especially in relation to the Epstein–Barr virus. The patient was a two-yr-old female child with biliary atresia who underwent a liver transplantation from a female cadaver donor. Two adults received kidney transplants from the same donor. Nine months after transplantation, one of the adult recipients developed an urothelial tumor in the kidney graft. Imaging tests were repeated monthly in the liver-transplanted child and revealed no abnormalities. However, one yr and two months after the transplantation, the patient developed episodes of fever. At that time, imaging and liver biopsy showed a clear cell tumor of urothelial origin in the graft and the disease was limited to the liver. The patient underwent liver retransplantation, and she is currently free of tumor recurrence. Although rare, the occurrence of tumors in the post-transplant period from cadaver donors, without previously diagnosed tumors, is one of the many problems encountered in the complex world of organ transplantation.