Bilateral lung transplant for hereditary hemorrhagic telangiectasia in a pediatric patient

Authors


Debra Boyer, MD, Children’s Hospital Boston, Division of Pediatric Pulmonology, 300 Longwood Ave. LO570, Boston, MA 02115, USA
Tel.: 617 355 1900
Fax: 617 730 0373
E-mail: debra.boyer@childrens.harvard.edu

Abstract

Misra MV, Mullen MP, Vargas SO, Kim HB, Boyer D. Bilateral lung transplant for hereditary hemorrhagic telangiectasia in a pediatric patient.

Abstract:  HHT is an autosomal dominant vascular dysplasia, in which abnormalities of endothelial cells cause patients to develop mucocutaneous telangiectasias, and AVMs of the pulmonary, hepatic, and cerebral circulations. Pulmonary AVMs occur in more than 20% of patients with HHT, and presentation varies from simple diffuse telangiectasias to large complex structures. Surgical management is usually indicated for large pulmonary AVMs. Treatment options for pulmonary AVMs include therapeutic embolization, segmental or lobar resection of the affected lung, and less commonly lung transplantation. Here we report the first successful case of a bilateral lung transplant for a four-yr-old girl with HHT.

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