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Chronic immune-mediated axonal polyneuropathy following umbilical cord blood transplant for childhood-onset cerebral adrenoleukodystrophy

Authors


Takeo Kato, Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
Tel.: +81 75 751 3291
Fax: +81 75 752 2361
E-mail: takeo819@kuhp.kyoto-u.ac.jp

Abstract

Shibata M, Kato T, Awaya T, Adachi S, Heike T. Chronic immune-mediated axonal polyneuropathy following umbilical cord blood transplant for childhood-onset cerebral adrenoleukodystrophy.

Abstract:  Peripheral polyneuropathy is an unusual complication after organ transplantation and HSCT. The present study describes the case of an eight-yr-old boy diagnosed with ALD who underwent HLA-matched UCBT under a reduced-intensity conditioning regimen and developed progressive walking difficulty and hand clumsiness 11 months after transplantation. These symptoms were associated with cGVHD, identified as immune-mediated axonopathy by electrophysiological examination and sural nerve biopsy. Peripheral polyneuropathy should be kept in mind as a complication of GVHD.

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