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Colitis in a renal transplant patient with human herpesvirus-6 infection


Correspondence to:
Michael S. Delbridge
Sheffield Kidney Institute
Northern General Hospital
Herries Road
Sheffield S5 7AU
Tel: +44 (0)114 271 4808
Fax: +44 (0)114 256 2514


Abstract: A male patient developed colitis and a thrombotic microangiopathy 3 weeks after renal transplantation. Immunosuppression at the time of presentation was with sirolimus, mycophenolate mofetil, and prednisolone, but without a calcineurin inhibitor. Cytomegalovirus infection was excluded. However, human herpesvirus-6 DNA was detected at high copy number in both blood and colonic epithelium. The patient recovered after reduction in immunosuppression, with nutritional support and ganciclovir therapy.