Varicella zoster virus-associated disease in adult kidney transplant recipients: incidence and risk-factor analysis
Article first published online: 11 DEC 2007
© 2008 Wiley Periodicals, Inc.
Transplant Infectious Disease
Volume 10, Issue 4, pages 260–268, August 2008
How to Cite
Arness, T., Pedersen, R., Dierkhising, R., Kremers, W. and Patel, R. (2008), Varicella zoster virus-associated disease in adult kidney transplant recipients: incidence and risk-factor analysis. Transplant Infectious Disease, 10: 260–268. doi: 10.1111/j.1399-3062.2007.00289.x
- Issue published online: 23 JUL 2008
- Article first published online: 11 DEC 2007
- Received 23 January 2007, revised 28 May, 21 August 2007, accepted for publication 20 September 2007
- herpes zoster;
- kidney transplant
Abstract: Varicella zoster virus (VZV)-related disease, particularly herpes zoster, is a complication of organ transplantation due to long-term immunosuppression. We determined the incidence and risk factors for post-transplant VZV infection by retrospectively reviewing the medical records of a cohort of 612 adult renal transplant recipients transplanted at Mayo Clinic Rochester between October 1, 2001 and October 1, 2004. Thirty-seven subjects developed herpes zoster, corresponding to a follow-up time-adjusted incidence of 11.2% at 4 years post transplant. The incidence rate of zoster was relatively constant between 6 months and 4 years, yielding an average incidence of approximately 28 per 1000 person-years. The risk of developing post-transplant zoster increased with increasing age at transplant, with each decade conferring a 1.42-fold (P=0.009) increase in risk of zoster development. Seronegativity at time of transplant conferred over 3 times the risk of development of post-transplant zoster (hazard ratio 3.4; P=0.04) compared with seropositivity. Adult kidney transplant recipients are at high risk for the development of post-transplant zoster.