Malassezia: is it a pulmonary pathogen in the stem cell transplant population?
Article first published online: 21 MAY 2009
© 2009 John Wiley & Sons A/S
Transplant Infectious Disease
Volume 11, Issue 4, pages 313–317, August 2009
How to Cite
Blaes, A.H., Cavert, W.P. and Morrison, V.A. (2009), Malassezia: is it a pulmonary pathogen in the stem cell transplant population?. Transplant Infectious Disease, 11: 313–317. doi: 10.1111/j.1399-3062.2009.00404.x
- Issue published online: 4 AUG 2009
- Article first published online: 21 MAY 2009
- Received 17 November 2008, revised 28 December 2008, accepted for publication 10 January 2009
- stem cell transplantation;
- Malassezia furfur;
Abstract: Malassezia furfur is a yeast that can cause a variety of infections, most commonly in normal hosts, and also in immunocompromised hosts. This yeast typically colonizes the skin, and is the causative agent of tinea versicolor. However, in immunocompromised hosts, it can more commonly cause catheter-related fungemia or folliculitis. Pulmonary infections from Malassezia have not been commonly recognized. Unlike many other common opportunistic fungal infections in immunocompromised hosts, neutropenia and the use of broad-spectrum antibiotics do not appear to be significant risk factors for Malassezia infections in the stem cell transplant (SCT) population. Additionally, disseminated infection, despite fungemia, is uncommon. A series of patients who underwent SCT at the University of Minnesota between 2004 and 2006 were reviewed for the occurrence of suspected Malassezia infections in the post-transplant period. Four cases of possible pulmonary M. furfur infection were identified in our SCT recipients. The clinical characteristics of these patients, the infections, treatment, and outcome are described. In addition, we discuss the possible pathogenicity of this yeast in the pulmonary setting.