• adenovirus;
  • disseminated;
  • nephritis;
  • transplant;
  • cidofovir

K. Sujeet, B. Vasudev, P. Desai, J. Bellizzi, L. Novoa-Takara, C. He, A. El-Meanawy. Acute kidney injury requiring dialysis secondary to adenovirus nephritis in renal transplant recipient Transpl Infect Dis 2011: 13: 174–177. All rights reserved

Abstract: Disseminated adenoviral infection is a serious problem, especially in an immunocompromised host. The disease carries a mortality rate reaching as high as 80%. It is seen most frequently in bone marrow transplant recipients, where it causes pneumonia and disseminated disease. In solid organ transplant recipients it causes graft infection. We report the case of a renal transplant recipient with disseminated adenoviral infection and acute kidney failure requiring dialysis. Reduction of immunosuppression and 1 dose of cidofovir were associated with resolution of viremia and viruria and return of kidney function to near baseline.