BK virus encephalitis with thrombotic microangiopathy in an allogeneic hematopoietic stem cell transplant recipient

Authors



Rodrigo Lopes da Silva, Serviço Transplantação Progenitores Hematopoiéticos, Instituto Português de Oncologia de Lisboa; Serviço de Hematologia, Hospital Santo António dos Capuchos; Rua Professor Lima Basto 73, 1070 Lisbon, Portugal
Tel: +351 21 722 98 64/21 720 04 52
Fax: +351 21 722 98 63
E-mail: ronolosi@gmail.com

Abstract

R. Lopes da Silva, I. Ferreira, G. Teixeira, D. Cordeiro, M. Mafra, I. Costa, J.M. Bravo Marques, M. Abecasis. BK virus encephalitis with thrombotic microangiopathy in an allogeneic hematopoietic stem cell transplant recipient.
Transpl Infect Dis 2011: 13: 161–167. All rights reserved

Abstract: BK virus (BKV) infection occurs most often in immunocompromised hosts, in the setting of renal or bone marrow transplantation. Hemorrhagic cystitis is the commonest manifestation but in recent years infections in other organ systems have been reported. We report an unusual case of biopsy-proven BKV encephalitis in a hematopoietic stem cell transplant patient who subsequently developed thrombotic microangiopathy. As far as we know, this is the first report of such an association in a transplant patient.

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