Rapid acute onset of bronchiolitis obliterans syndrome in a lung transplant recipient after respiratory syncytial virus infection


Correspondence to:

Don Hayes Jr, MD, MS, MEd

The Ohio State University

700 Children's Drive

Columbus, OH 43205 USA

Tel: 614 722-4766

Fax: 614 722-4755

E-mail: don.hayes@nationwidechildrens.org


Bronchiolitis obliterans syndrome (BOS) can have either an acute or chronic onset with an abrupt or insidious course. The diagnosis is typically achieved by physiological criteria with development of a sustained decline in expiratory flow rates for at least 3 weeks. We review the rapid development of acute BOS and bronchiectasis after respiratory syncytial virus infection in a lung transplant recipient, who had been doing well with normal pulmonary function for 3 years after lung transplantation.