Skeletal muscle lipid accumulation in obesity, insulin resistance, and type 2 diabetes

Authors

  • Bret H Goodpaster,

    Corresponding author
    1. Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
      *Bret H. Goodpaster
      Assistant Professor of Medicine
      Division of Endocrinology and Metabolism
      Department of Medicine
      University of Pittsburgh
      3459 Fifth Avenue
      Montefiore Hospital N807
      Pittsburgh, PA 15213, USA
      Tel: +1 412 692 2158;
      fax: +1 412 692 2165;
      e-mail: bgood@pitt.edu
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  • Donna Wolf

    1. Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Search for more papers by this author

*Bret H. Goodpaster
Assistant Professor of Medicine
Division of Endocrinology and Metabolism
Department of Medicine
University of Pittsburgh
3459 Fifth Avenue
Montefiore Hospital N807
Pittsburgh, PA 15213, USA
Tel: +1 412 692 2158;
fax: +1 412 692 2165;
e-mail: bgood@pitt.edu

Abstract

Abstract:  In addition to obesity, many factors, including the distribution of body fat, contribute to the development of insulin resistance and type 2 diabetes mellitus (T2DM). Lipid contained within skeletal muscle as triglyceride is a parameter of regional fat accumulation thought to be an important link among obesity, insulin resistance, and type 2 diabetes, even in the pediatric population. Intramuscular triglycerides can also be a fuel source for healthy muscle during periods of physical activity. Thus, the balance between storage and efficient utilization of muscle triglycerides is likely a key to a better understanding of the interaction between dysregulated fat and glucose metabolism by muscle in both adults and children. This review examines the evidence that muscle lipid accumulation is linked with insulin resistance and type 2 diabetes of both adults and children. In addition, we explore the potential mechanisms for muscle lipid accumulation as well as the effects of weight loss and physical activity on muscle lipid. Further defining the links between muscle lipid accumulation and insulin action should help develop more effective strategies to prevent or treat type 2 diabetes and other obesity-associated disorders.

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