Association of the PTPN22/LYP gene with type 1 diabetes

  1. Andrea K Steck1,†,
  2. Si-Yang Liu2,3,†,
  3. Kim McFann1,
  4. Katherine J Barriga4,
  5. Sunanda R Babu1,
  6. George S Eisenbarth1,
  7. Marian J Rewers1,4,
  8. Jin-Xiong She2,*

Article first published online: 18 OCT 2006

DOI: 10.1111/j.1399-5448.2006.00202.x

Issue

Pediatric Diabetes

Pediatric Diabetes

Volume 7, Issue 5, pages 274–278, October 2006

Additional Information

How to Cite

Steck, A. K., Liu, S.-Y., McFann, K., Barriga, K. J., Babu, S. R., Eisenbarth, G. S., Rewers, M. J. and She, J.-X. (2006), Association of the PTPN22/LYP gene with type 1 diabetes. Pediatric Diabetes, 7: 274–278. doi: 10.1111/j.1399-5448.2006.00202.x

Author Information

  1. 1

    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO USA

  2. 2

    Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, GA, USA

  3. 3

    Key Laboratory of Development Biology in Education Department, College of Life Science, Wuhan University, Wuhan, China

  4. 4

    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, CO, USA

  1. †

    These authors contributed equally to the study.

*Jin-Xiong She, PhD, Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912-2400, USA. Tel: 706-721-3410; fax: 706-721-3688; e-mail: jshe@mail.mcg.edu

Publication History

  1. Issue published online: 18 OCT 2006
  2. Article first published online: 18 OCT 2006
  3. Submitted 16 February 2006. Accepted for publication 6 July 2006

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Keywords:

  • case;
  • control study;
  • HLA;
  • LYP;
  • PTPN22 gene;
  • type 1 diabetes

Objectives:  The goal of this study was to verify the association between type 1 diabetes (T1D) and the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene in non-Hispanic whites (NHWs) and Hispanics from Colorado.

Subjects and methods:  The C1858T single-nucleotide polymorphism within the PTPN22 gene was genotyped in 753 patients with T1D ascertained from the diabetes clinic at the Barbara Davis Center in Denver and 662 control population.

Results:  Both the PTPN22 CT genotype [odds ratio (OR) = 1.96; p < 0.0001] and TT genotype (OR = 4.41; p = 0.02) were significantly associated with T1D in the NHW population. While the association was stronger in subjects with non-HLA-DR3/4 genotypes than in those with the HLA-DR3/4 genotype, regression analyses did not reveal significant interaction between PTPN22 genotypes and HLA-DR3/4. The strength of the association was similar in males and females, patients diagnosed before and after age 10 yr, and in Hispanics and NHWs.

Conclusion:  In this study, we confirm that PTPN22 is associated with T1D in the Colorado population.

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