These authors contributed equally to the study.
Association of the PTPN22/LYP gene with type 1 diabetes
Article first published online: 18 OCT 2006
2006 Blackwell Munksgaard
Volume 7, Issue 5, pages 274–278, October 2006
How to Cite
Steck, A. K., Liu, S.-Y., McFann, K., Barriga, K. J., Babu, S. R., Eisenbarth, G. S., Rewers, M. J. and She, J.-X. (2006), Association of the PTPN22/LYP gene with type 1 diabetes. Pediatric Diabetes, 7: 274–278. doi: 10.1111/j.1399-5448.2006.00202.x
- Issue published online: 18 OCT 2006
- Article first published online: 18 OCT 2006
- Submitted 16 February 2006. Accepted for publication 6 July 2006
- control study;
- PTPN22 gene;
- type 1 diabetes
Objectives: The goal of this study was to verify the association between type 1 diabetes (T1D) and the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene in non-Hispanic whites (NHWs) and Hispanics from Colorado.
Subjects and methods: The C1858T single-nucleotide polymorphism within the PTPN22 gene was genotyped in 753 patients with T1D ascertained from the diabetes clinic at the Barbara Davis Center in Denver and 662 control population.
Results: Both the PTPN22 CT genotype [odds ratio (OR) = 1.96; p < 0.0001] and TT genotype (OR = 4.41; p = 0.02) were significantly associated with T1D in the NHW population. While the association was stronger in subjects with non-HLA-DR3/4 genotypes than in those with the HLA-DR3/4 genotype, regression analyses did not reveal significant interaction between PTPN22 genotypes and HLA-DR3/4. The strength of the association was similar in males and females, patients diagnosed before and after age 10 yr, and in Hispanics and NHWs.
Conclusion: In this study, we confirm that PTPN22 is associated with T1D in the Colorado population.