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Hs-CRP is associated with weight, BMI, and female sex but not with endothelial function in children with type 1 diabetes

  1. Karen E MacKenzie1,2,*,
  2. Esko J Wiltshire3,
  3. Alexia S Peña1,2,
  4. Roger Gent4,
  5. Craig Hirte5,
  6. Lino Piotto4,
  7. Jennifer J Couper1,2

Article first published online: 15 SEP 2008

DOI: 10.1111/j.1399-5448.2008.00456.x

Issue

Pediatric Diabetes

Pediatric Diabetes

Volume 10, Issue 1, pages 44–51, February 2009

Additional Information

How to Cite

MacKenzie, K. E., Wiltshire, E. J., Peña, A. S., Gent, R., Hirte, C., Piotto, L. and Couper, J. J. (2009), Hs-CRP is associated with weight, BMI, and female sex but not with endothelial function in children with type 1 diabetes. Pediatric Diabetes, 10: 44–51. doi: 10.1111/j.1399-5448.2008.00456.x

Author Information

  1. 1

    Department of Diabetes and Endocrinology, Women’s and Children’s Hospital, Adelaide, South Australia, Australia

  2. 2

    Discipline of Paediatrics, University of Adelaide, Adelaide, South Australia, Australia

  3. 3

    Department of Paediatrics, University of Otago, Wellington, New Zealand

  4. 4

    Department of Medical Imaging, Women’s and Children’s Hospital, Adelaide, South Australia, Australia

  5. 5

    Public Health Research Unit, Children, Youth and Women’s Service, Adelaide, South Australia, Australia

*Dr Karen E MacKenzie Paediatric Department Christchurch Hospital Private Bag 4710 Christchurch 8000 New Zealand. Tel: +64 3 3640640; fax: +64 3 3640919; e-mail: karen.mackenzie@cdhb.govt.nz

Publication History

  1. Issue published online: 20 JAN 2009
  2. Article first published online: 15 SEP 2008
  3. Submitted 9 January 2008. Accepted for publication 24 June 2008

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Keywords:

  • CRP;
  • T1DM;
  • vascular endothelium-dependent relaxation

Background:  Atherosclerosis is an inflammatory process, and high-sensitivity C-reactive protein (Hs-CRP), a marker of inflammation, predicts cardiovascular events in adults. Vascular endothelial and smooth muscle dysfunction, measurable precursors of atherosclerosis, begin in childhood. Therefore, we sought to determine if Hs-CRP is associated with vascular endothelial and smooth muscle dysfunction in children with type 1 diabetes mellitus (T1DM) and healthy control subjects.

Methods:  Hs-CRP and endothelial function assessed by flow-mediated dilatation (FMD) and smooth muscle function assessed by glyceryl-trinitrate (GTN)-induced dilatation were measured in 121 subjects with T1DM aged 14.1 (2.9) yr, of whom 31 were also studied at 4 and 8 wk, and in 33 healthy controls aged 14.2 (3.6) yr.

Results:  Hs-CRP did not differ between subjects with T1DM and healthy, age-matched controls. In both controls and subjects with T1DM, Hs-CRP did not relate to FMD or GTN at baseline or at intervals over 8 wk in T1DM. Hs-CRP did not change over time. In T1DM, but not healthy controls, Hs-CRP related to body mass index (BMI) z-score (r = 0.47, p < 0.001), weight z-score (r = 0.41, p < 0.001), and female sex (p = 0.008).

Conclusions:  Hs-CRP is not associated with early vascular dysfunction in children with T1DM. However, in children and adolescents with T1DM, Hs-CRP was associated with female sex and children with higher BMI, suggesting that these groups may be at greater cardiovascular risk. Maintenance of a healthy BMI may be important in the prevention of vascular disease of T1DM.

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