The effectiveness of glucose, sucrose, and fructose in treating hypoglycemia in children with type 1 diabetes
Article first published online: 3 AUG 2009
© 2009 John Wiley & Sons A/S
Volume 11, Issue 3, pages 154–158, May 2010
How to Cite
Husband, A. C., Crawford, S., McCoy, L. A. and Pacaud, D. (2010), The effectiveness of glucose, sucrose, and fructose in treating hypoglycemia in children with type 1 diabetes. Pediatric Diabetes, 11: 154–158. doi: 10.1111/j.1399-5448.2009.00558.x
- Issue published online: 27 APR 2010
- Article first published online: 3 AUG 2009
- Submitted 10 March 2009. Accepted for publication 22 June 2009
- type 1 diabetes
Husband AC, Crawford S, McCoy LA, Pacaud D. The effectiveness of glucose, sucrose, and fructose in treating hypoglycemia in children with type 1 diabetes.
Objective: There is a lack of evidence regarding the most effective treatment option for managing naturally occurring hypoglycemia in children with type 1 diabetes. The objectives of this study were (i) to determine if sucrose and fructose are equally effective as glucose in the treatment of spontaneous hypoglycemia in children with type 1 diabetes; and (ii) to determine prestudy and poststudy hypoglycemia treatment preferences.
Methods: Thirty-three subjects [aged 5.4–15.5 yr and average duration of type 1 diabetes of 3.1 yr (SD = 2.3)] participated in a randomized, crossover design. The main outcome was the effectiveness of treatment as defined by a blood glucose meter reading that was ≥ 4.0 mmol/L 15 min after treatment. Each subject treated five hypoglycemic events with each treatment type: glucose (BD Glucose Tablets™), sucrose (Skittles™), and fructose (Fruit to Go™).
Results: There was a significant difference between the effectiveness of the three treatments [Wilk's Lambda F(2,28) = 8.64, p = 0.001]. No significant difference between treatment with glucose and treatment with sucrose was noted, but the treatment effectiveness for fructose was significantly lower than sucrose [F (1,29) = 16.09, p < 0.001] and glucose [F (1,29) = 15.64, p < 0.001]. The preferred treatment choices before the study were as follows: 36% glucose, 18% sucrose, and 33% fructose sources. Poststudy, 52% of children preferred the same treatment, which was effective (glucose or sucrose), followed by 35% who changed their preference to an effective treatment.
Conclusion: Skittles™ are as effective in treating hypoglycemia as more expensive BD Glucose Tablets™ in children with type 1 diabetes.