Correlates of glycemic control and quality of life outcomes in adolescents with type 1 diabetes

Authors

  • Lisa M Ingerski,

    1. Center for Treatment Adherence, Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
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  • Lori Laffel,

    1. Pediatric, Adolescent, and Young Adult Section, Genetics and Epidemiology Section, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA
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  • Dennis Drotar,

    1. Center for Treatment Adherence, Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
    2. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
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  • David Repaske,

    1. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    2. Diabetes Center, Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
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  • Korey K Hood

    Corresponding author
    1. Center for Treatment Adherence, Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
    2. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
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Korey Hood, PhD
Center for the Promotion of Treatment Adherence and Self-Management Division of Behavioral Medicine and Clinical Psychology Cincinnati Children's Hospital Medical Center 3333 Burnet Avenue, MLC 7039 Cincinnati, OH 45229-3039 USA.
Tel: +1 513 8030405
fax: +1 513 8030415
e-mail: Korey.Hood@cchmc.org

Abstract

Ingerski LM, Laffel L, Drotar D, Repaske D, Hood KK. Correlates of glycemic control and quality of life outcomes in adolescents with type 1 diabetes.

Background: A major focus of pediatric multidisciplinary diabetes care is promoting glycemic control (A1c) while ensuring high quality of life (QOL). The current study investigated factors associated with A1c and QOL using a methodology that considered these variables as simultaneous outcomes.

Method: A total of 261 adolescents (aged 13–18) with type 1 diabetes completed measures of blood glucose monitoring (BGM) frequency, diabetes-specific QOL, negative affect, and depression. Caregivers completed measures of demographic and disease characteristics, depression, and family conflict.

Results: A1c was negatively correlated with QOL (r = −0.18 to −0.29, p < 0.01) across all subscales. Based on clinical A1c goals and median QOL scores, adolescents fell into four glycemic control–QOL groups. Multinomial logistic regression determined correlates of group membership utilizing adolescents with suboptimal glycemic control–low QOL as the referent group. Adolescents with optimal glycemic control–high QOL reported increased BGM frequency (OR = 1.87), less negative affect (OR = 1.32), and were more likely to use CSII (OR = 5.41). Adolescents with optimal A1c–low QOL reported greater BGM frequency (OR = 1.91) and shorter disease duration (OR = 1.09). Adolescents with suboptimal glycemic control–high QOL reported greater BGM frequency (OR = 1.41), fewer depressive symptoms (OR = 1.13), and less negative affect (OR = 1.31).

Conclusions: Results reveal disease, management, and psychosocial characteristics that differentiate glycemic control–QOL outcome groups and identify risk factors related to this relationship. Further appreciation of these characteristics may increase clinicians' understanding and attention to these important clinical outcomes and help tailor the most appropriate interventions (e.g., individual psychotherapy vs. family problem-solving interventions) to help adolescents achieve glycemic control without sacrificing QOL.

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