Ascorbic acid blocks hyperglycemic impairment of endothelial function in adolescents with type 1 diabetes

Authors

  • Robert P. Hoffman,

    Corresponding author
    1. Research Institute at Nationwide Children's Hospital, Columbus, OH, USA
    • Division of Pediatric Endocrinology, Metabolism and Diabetes, Department of Pediatrics, The Clinical Research Center of The Ohio State University College of Medicine and Public Health, Columbus, OH, USA
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  • Amanda S. Dye,

    1. Division of Pediatric Endocrinology, Metabolism and Diabetes, Department of Pediatrics, The Clinical Research Center of The Ohio State University College of Medicine and Public Health, Columbus, OH, USA
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  • John A. Bauer

    1. Research Institute at Nationwide Children's Hospital, Columbus, OH, USA
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Corresponding author:

Robert P. Hoffman, MD

Nationwide Children's Hospital

ED 422 700 Children's Drive, Columbus, OH 43205, USA.

Tel: 614-722-4425

fax: 614-722-4440

e-mail: Robert.Hoffman@nationwidechildrens.org

Abstract

Objective

To determine whether acute ascorbic acid infusions alter the effect of hyperglycemia on endothelial function in adolescents with type 1 diabetes.

Research design and methods

The forearm blood flow (FBF) reactive hyperemic response to 5 min of upper arm occlusion was studied in eight adolescents with type 1 diabetes during euglycemic and hyperglycemic insulin clamp (40 mU/m2/min) with and without ascorbic acid infusion (3 mg/min).

Results

The ratio of post- to preocclusion FBF decreased during hyperglycemia without ascorbic acid (p = 0.013), but did not change during hyperglycemia with ascorbic acid. The changes during hyperglycemia were different between the two studies (p = 0.038). Similar results were found when the percent change in forearm vascular resistance following occlusion was assessed.

Conclusions

These results indicate that antioxidant treatment with ascorbic acid blocks acute hyperglycemic impairment of endothelial function in adolescents with type 1 diabetes.

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