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Keywords:

  • incidence;
  • Republic of Srpska;
  • Slovenia;
  • type 1 diabetes mellitus

Abstract

Objective

To establish and compare the incidence and trends of type 1 diabetes mellitus (T1DM) in Republic of Srpska and Slovenia in age group 0–18 yr from 1998 to 2010.

Methods

The subjects (413 newly diagnosed T1DM patients in the Republic of Srpska and 664 in Slovenia) were grouped into the age groups: 0–4, 5–9, 10–14, and 15–18 yr. Confidence intervals (CI) for crude incidence rates were estimated assuming numbers of cases were counts from the Poisson distribution. Gender and age-specific standardization was done according to the EURODIAB criteria. Statistical analysis used Poisson-regression models to analyze difference rate between countries and to investigate the incidence trend.

Results

Case ascertainment was estimated to be 99.95% for the Republic of Srpska and 100% for Slovenia by using the capture–recapture method. The standardized incidence of T1DM for age group 0–18 yr in the Republic of Srpska was 7.5/100 000/yr (95% CI: 6.8–8.3). For the same period and the same age group incidence in Slovenia was 12.5/100 000/yr (95% CI: 11.5–13.5). Annual increase in the incidence in the Republic of Srpska was 2.3% (95% CI: −0.3 to 5.0%), whereas in Slovenia 4.3% (95% CI: 2.2–6.5%).

Conclusion

The incidence for age group 0–18 yr standardized to the world population is remarkably higher in Slovenia than in the Republic of Srpska. Further follow-up and investigations are needed to explain the high difference in incidence of T1DM between the two geographically related countries.