pedi917-sup-0001-FigureS1.docWord document89KFig. S1. Sequences of the four INS and one KCNJ11 mutations. The mutations were sequenced as C31Y (c.92G>A, p.Cys31Tyr), R89C (c.265C>T, p.Arg89Cys), C96R (c.286T>C, p.Cys96Arg), and C109F (c.326G>T, p.Cys109Phe) in INS gene and H46R (c.137A>G, p.His46Arg) in KCNJ11 gene. The red arrows indicate the positions of the mutations.
pedi917-sup-0002-FigureS2.docWord document56KFig. S2. Multiple alignment of the amino acids sequences of insulin from different species showing the positions of diabetes-related mutations. Amino acids conserved in all 10 species are indicated in black boxes. The arrows indicate the positions of C31Y, R89C, C96R, and C109F. Red asterisks indicate the positions that affect residues conserved in all 10 species.
pedi917-sup-0003-TableS1.docWord document68KTable S1. Primers used for INS and KCNJ11 gene PCR, sequencing analysis and PCR-RFLP

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