The authors of this paper do not have any commercial associations that might post a conflict of interest in connection with this manuscript.
Clinical correlates and significance of separation anxiety in patients with bipolar disorder
Article first published online: 15 JUL 2005
Volume 7, Issue 4, pages 370–376, August 2005
How to Cite
Pini, S., Abelli, M., Mauri, M., Muti, M., Iazzetta, P., Banti, S. and Cassano, G. B. (2005), Clinical correlates and significance of separation anxiety in patients with bipolar disorder. Bipolar Disorders, 7: 370–376. doi: 10.1111/j.1399-5618.2005.00216.x
- Issue published online: 15 JUL 2005
- Article first published online: 15 JUL 2005
- Received 31 December 2003, revised and accepted for publication 31 January 2005
- adulthood separation anxiety;
- bipolar disorder;
- childhood separation anxiety disorder;
- panic disorder
Objectives: To evaluate frequency and severity of separation anxiety (SA) symptoms, as well as frequency of DSM-IV diagnosis of childhood separation anxiety disorder (CSAD) and adult separation anxiety disorder (ASAD), in a group of patients with bipolar disorder (BD) when compared with patients with panic disorder (PD) or major depression (MDD) and to a control group of healthy individuals (HC).
Methods: Outpatients with, respectively, bipolar I disorder (BD), PD, MDD and a group of individuals with no psychiatric diagnoses (HC) were assessed for diagnosis by the SCID-I and for SA by the Structured Clinical Interview for Separation Anxiety Symptoms (SCI-SAS), the Separation Anxiety Symptoms Inventory (SASI) and the Adult Separation Anxiety Checklist (ASA-CL).
Results: Thirty-one patients with BD without comorbid PD (BD-PD), 22 with BD with comorbid PD (BD + PD), 24 with PD, 20 with MDD and 15 HC were included in the analyses. As to childhood SA, the BD-PD group had higher scores than PD group and HC. The BD + PD group had higher scores than the PD group, MDD group and HC. As to adulthood SA, the BD-PD group had higher scores than HC on both SCI-SAS and Adult Separation Anxiety Questionnaire (ASA-27). The BD + PD had higher scores on both scales than BD-PD, PD group, MDD group and HC. The PD group and MDD group had higher scores than HC on the ASA-27. Adult SA symptoms were significantly associated with an earlier age at onset of BD.
Conclusions: This is the first study, to our knowledge, exploring the frequency and severity of SA symptoms during childhood and adulthood in a sample of bipolar patients in comparison to subjects with other anxiety and mood disorders. Our data appear to be preliminary grounds for investigating further the possibility that SA may deserve greater recognition in adults with BD.