An emotional Stroop functional MRI study of euthymic bipolar disorder
Article first published online: 14 OCT 2005
Volume 7, Issue Supplement s5, pages 58–69, December 2005
How to Cite
Malhi, G. S., Lagopoulos, J., Sachdev, P. S., Ivanovski, B. and Shnier, R. (2005), An emotional Stroop functional MRI study of euthymic bipolar disorder. Bipolar Disorders, 7: 58–69. doi: 10.1111/j.1399-5618.2005.00255.x
- Issue published online: 14 OCT 2005
- Article first published online: 14 OCT 2005
- bipolar disorder;
- mood induction;
Objective: To identify the brain regions associated with emotional processing in euthymic bipolar patients.
Methods: The study examined 12 euthymic bipolar patients using functional magnetic resonance imaging (fMRI) while performing an emotional Stroop (eStroop) task. The task comprised emotionally valent and neutral words presented in alternating blocks that was designed to implicitly induce affect. In conjunction with fMRI, galvanic skin responses (GSR) were measured to monitor arousal.
Results: Euthymic bipolar patients had diminished activation in response to the affective stimuli in both cortical and subcortical brain regions when compared with healthy subjects. In particular, patients had less activation in the left ventral prefrontal cortex suggesting a potential trait deficit. Patients were slower to react than healthy controls, but did not differ with respect to accuracy.
Conclusions: Euthymic bipolar patients are perhaps constrained in their ability to engage affective processing. Diminished ventral prefrontal cortex activation corroborates previous reports of a potential trait deficit, suggesting that ‘all is not well in euthymia’, although the effects of medication cannot be overlooked.