The authors of this paper do not have any commercial associations that might pose a conflict of interest in connection with this manuscript.
The CBCL predicts DSM bipolar disorder in children: a receiver operating characteristic curve analysis
Article first published online: 8 DEC 2005
Volume 7, Issue 6, pages 518–524, December 2005
How to Cite
Faraone, S. V., Althoff, R. R., Hudziak, J. J., Monuteaux, M. and Biederman, J. (2005), The CBCL predicts DSM bipolar disorder in children: a receiver operating characteristic curve analysis. Bipolar Disorders, 7: 518–524. doi: 10.1111/j.1399-5618.2005.00271.x
- Issue published online: 8 DEC 2005
- Article first published online: 8 DEC 2005
- Received 25 May 2005, revised and accepted for publication 26 September 2005
- attention-deficit hyperactivity disorder;
- bipolar affective disorder;
- Child Behavior Checklist;
- pediatric bipolar
Background: No clear consensus has been reached yet on how best to characterize children who suffer from pediatric bipolar disorder (PBD). The CBCL-PBD profile on the Child Behavior Checklist (CBCL) has been consistently reported showing deviant findings on the Attention Problems, Aggressive Behavior, and Anxious-Depressed subscales.
Aim: To examine the sensitivity and specificity of the proposed CBCL-PBD profile for determining DSM diagnosis of PBD.
Methods: We applied receiver operating characteristic (ROC) curve analysis to data from 471 probands from two family studies of attention-deficit hyperactivity disorder and their 410 siblings.
Results: The CBCL-PBD score demonstrated an area under the curve (AUC) of 0.97 for probands and 0.82 for siblings for current diagnosis of PBD, suggesting that the CBCL-PBD provided a highly efficient way of identifying subjects with a current diagnosis of PBD in this sample.
Conclusions: These findings suggest that the CBCL-PBD may provide a highly efficient way of screening for childhood bipolar disorder.