The authors of this paper do not have any commercial associations that might pose a conflict of interest in connection with this manuscript.
Duplication 8q22.1-q24.1 associated with bipolar disorder and speech delay
Version of Record online: 12 MAY 2006
Volume 8, Issue 3, pages 294–298, June 2006
How to Cite
Macayran, J., Brodie, S., Rao, P., O'Connor, M., Gray, J., Ciarimboli, B. and Dipple, K. (2006), Duplication 8q22.1-q24.1 associated with bipolar disorder and speech delay. Bipolar Disorders, 8: 294–298. doi: 10.1111/j.1399-5618.2006.00306.x
- Issue online: 12 MAY 2006
- Version of Record online: 12 MAY 2006
- Received 7 June 2005, revised and accepted for publication 26 December 2005
- autoimmune thyroiditis;
- bipolar disorder;
- 8q duplication
Objective: To report a case of a child with bipolar disorder found to have an unbalanced translocation involving the long arm of chromosome 8, a region that has been previously implicated in genome-wide linkage scans.
Case report: A 7-year-old boy with a complex psychiatric symptom presentation including attention deficits, distractibility, impulsivity, pressured speech, sleep disturbance, aggressive behavior, and hypersexuality diagnosed with bipolar disorder. He also showed evidence of borderline intellectual and adaptive functioning and had mild dysmorphic features with a duplication of distal 8q that arose as an unbalanced chromosomal translocation due to a maternal 15p;8q insertion.
Conclusion: This finding of an unbalanced translocation provides further evidence to support previous linkage studies of a potential causative gene on 8q for bipolar disorder.