Olanzapine in the prevention of postpartum psychosis and mood episodes in bipolar disorder

Authors


  • The authors of this paper do not have any commercial associations that might pose a conflict of interest in connection with this manuscript.

Verinder Sharma, Mood Disorders Program, Regional Mental Health Care London, 850 Highbury Avenue North, PO Box 5532, Station B, London, ON, Canada N6A 4H1. Fax: (519) 455 3011; e-mail: vsharma@uwo.ca

Abstract

Objectives:  The use of olanzapine (OLZ) in the prevention of postpartum psychosis (PP) and mood episodes in women with bipolar disorder was investigated in a naturalistic, prospective study.

Methods:  Eleven women received OLZ alone or in combination with an antidepressant or mood stabilizer, and 14 women received either antidepressants, mood stabilizers, or no medication for a minimum of 4 weeks after delivery.

Results:  Two (18.2%) of the women in the OLZ group experienced a postpartum mood episode, whereas eight (57.1%) of the women in the No-OLZ group did.

Conclusions:  The role of OLZ in the prophylaxis of PP and mood episodes, particularly in women at high risk, clearly warrants further investigation.

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