The authors of this paper do not have any commercial associations that might pose a conflict of interest in connection with this manuscript.
Olanzapine in the prevention of postpartum psychosis and mood episodes in bipolar disorder
Version of Record online: 18 JUL 2006
Volume 8, Issue 4, pages 400–404, August 2006
How to Cite
Sharma, V., Smith, A. and Mazmanian, D. (2006), Olanzapine in the prevention of postpartum psychosis and mood episodes in bipolar disorder. Bipolar Disorders, 8: 400–404. doi: 10.1111/j.1399-5618.2006.00335.x
- Issue online: 18 JUL 2006
- Version of Record online: 18 JUL 2006
- Received 17 December 2004, revised and accepted for publication 17 February 2006
- bipolar I disorder;
- bipolar II disorder;
- childbirth prevention;
Objectives: The use of olanzapine (OLZ) in the prevention of postpartum psychosis (PP) and mood episodes in women with bipolar disorder was investigated in a naturalistic, prospective study.
Methods: Eleven women received OLZ alone or in combination with an antidepressant or mood stabilizer, and 14 women received either antidepressants, mood stabilizers, or no medication for a minimum of 4 weeks after delivery.
Results: Two (18.2%) of the women in the OLZ group experienced a postpartum mood episode, whereas eight (57.1%) of the women in the No-OLZ group did.
Conclusions: The role of OLZ in the prophylaxis of PP and mood episodes, particularly in women at high risk, clearly warrants further investigation.