The authors of this paper do not have any commercial associations that might pose a conflict of interest in connection with this manuscript.
Rational approaches to the neurobiologic study of youth at risk for bipolar disorder and suicide
Article first published online: 17 OCT 2006
Volume 8, Issue 5p2, pages 526–542, October 2006
How to Cite
Elizabeth Sublette, M., Oquendo, M. A. and John Mann, J. (2006), Rational approaches to the neurobiologic study of youth at risk for bipolar disorder and suicide. Bipolar Disorders, 8: 526–542. doi: 10.1111/j.1399-5618.2006.00372.x
- Issue published online: 17 OCT 2006
- Article first published online: 17 OCT 2006
- Received 28 April 2005, revised and accepted for publication 15 May 2006
- bipolar disorder;
Objectives: The aims of this paper are to provide an overview of neuroimaging findings specific to bipolar disorder and suicide, and to consider rational approaches to the design of future in vivo studies in youth at risk.
Methods: Neuroimaging and related neurobiological literature pertaining to bipolar disorder and suicide in adult and pediatric samples was reviewed in a non-quantitative manner.
Results: Specific structural and functional brain findings in bipolar disorder are described, where possible in the context of relevant current neurobiological theories of etiology. Diagnostic and prognostic implications are discussed.
Conclusions: The simultaneous use of complementary neurobiological approaches may be a powerful way of identifying and validating factors reliably associated with bipolar disorder and suicide. A profile of neurobiological markers with which to screen for bipolar disorder and suicide risk may provide for earlier and more accurate diagnosis, perhaps even in the pre- or subsyndromal stages in high-risk youth.