The authors of this paper do not have any commercial associations that might pose a direct conflict of interest in connection with this manuscript.
White matter abnormalities in children with and at risk for bipolar disorder
Article first published online: 7 DEC 2007
Volume 9, Issue 8, pages 799–809, December 2007
How to Cite
Frazier, J. A., Breeze, J. L., Papadimitriou, G., Kennedy, D. N., Hodge, S. M., Moore, C. M., Howard, J. D., Rohan, M. P., Caviness, V. S. and Makris, N. (2007), White matter abnormalities in children with and at risk for bipolar disorder. Bipolar Disorders, 9: 799–809. doi: 10.1111/j.1399-5618.2007.00482.x
- Issue published online: 7 DEC 2007
- Article first published online: 7 DEC 2007
- Received 28 April 2006, revised and accepted for publication 11 December 2006
- bipolar disorder;
- child psychiatry;
- diffusion tensor imaging;
- magnetic resonance imaging;
- mood disorders
Objectives: Diffusion tensor magnetic resonance imaging (DT-MRI) assesses the integrity of white matter (WM) tracts in the brain. Children with bipolar disorder (BPD) may have WM abnormalities that precede illness onset. To more fully examine this possibility, we scanned children with DSM-IV BPD and compared them to healthy peers and children at risk for BPD (AR-BPD), defined as having a first-degree relative with the disorder.
Methods: Ten children with BPD, eight healthy controls (HC), and seven AR-BPD, similar in age, had MRI scans on a 1.5 Tesla GE scanner, including a standard DT-MRI sequence (T2-EPI) with 25 axial slices. Fractional anisotropy (FA) values were compared between groups to determine regions of significant difference (p < 0.05).
Results: Compared to HC, children with BPD had decreased FA in right and left superior frontal tracts, including the superior longitudinal fasciculus I (SLF I) and the cingulate-paracingulate WM (CG-PACWM). In addition, the BPD group had reduced FA in left orbital frontal WM and the right corpus callosum body. Compared to AR-BPD, children with BPD showed reduced FA in the right and left CG-PACWM. Both the BPD and AR-BPD groups showed reduced FA relative to HC in bilateral SLF I.
Conclusions: The bilateral SLF I finding in both the BPD and AR-BPD groups may represent a trait-based marker or endophenotype of the disorder. The finding of decreased FA in the right and left CG-PACWM in children with BPD compared to the other two groups may represent a disease-state related finding.