YMA has received grant/research support from Sanofi-aventis and GlaxoSmithKline. YHJ has received grant, research support, and/or honoraria from Pfizer, GlaxoSmithKline and AstraZeneca. YSK has received grant, research support, and/or honoraria from Norvatis, Janssen, Eli Lilly & Co., Pfizer, Sanofi-aventis, Otsuka, AstraZeneca, Organon, and GlaxoSmithKline, and was also supported by the second stage Brain Korea 21 Project in 2006.
Chronotype distribution in bipolar I disorder and schizophrenia in a Korean sample
Article first published online: 6 FEB 2008
© 2008 Blackwell Munksgaard
Volume 10, Issue 2, pages 271–275, March 2008
How to Cite
Ahn, Y. M., Chang, J., Joo, Y. H., Kim, S. C., Lee, K. Y. and Kim, Y. S. (2008), Chronotype distribution in bipolar I disorder and schizophrenia in a Korean sample. Bipolar Disorders, 10: 271–275. doi: 10.1111/j.1399-5618.2007.00573.x
- Issue published online: 6 FEB 2008
- Article first published online: 6 FEB 2008
- Received 16 May 2005, revised and accepted for publication 28 February 2007
- bipolar disorder;
Objectives: Although a broad range of circadian rhythm variations have been reported, analyses of chronotypes in bipolar I disorder (BDI) and schizophrenia are rare. The present study aimed to investigate specific chronotype patterns in BDI and schizophrenia compared with healthy subjects.
Methods: All patients were clinically stable and recruited from the outpatient clinics of Seoul National University Hospital. They were diagnosed according to DSM-IV criteria. ‘Morningness/eveningness’, a chronotype correlated with circadian phase, was evaluated using the Composite Scale of Morningness (CSM) among 92 patients with BDI, 113 patients with schizophrenia (SZ), and 95 control individuals.
Results: The CSM scores were significantly correlated with age in the control group, but a significant correlation with age was not observed in the schizophrenia or BDI groups. After controlling for age, there were significant differences between the BDI and control groups. The SZ patients did not differ from the BDI or control groups.
Conclusions: In this Korean sample, patients with BDI showed a significantly greater preference for ‘eveningness’ (including delayed sleep timing) than control individuals. The influences of pharmacotherapy or clinical status on CSM scores need to be clarified.