The authors of this paper do not have any commercial associations that might pose a conflict of interest in connection with this manuscript.
Gender influences the detection of spatial working memory deficits in bipolar disorder
Article first published online: 4 JUL 2008
© 2008 The Authors. Journal compilation © 2008 Blackwell Munksgaard
Volume 10, Issue 5, pages 647–654, August 2008
How to Cite
Barrett, S. L., Kelly, C., Bell, R. and King, D. J. (2008), Gender influences the detection of spatial working memory deficits in bipolar disorder. Bipolar Disorders, 10: 647–654. doi: 10.1111/j.1399-5618.2008.00592.x
- Issue published online: 4 JUL 2008
- Article first published online: 4 JUL 2008
- Received 1 September 2006, revised and accepted for publication 30 April 2007
- bipolar disorder;
- executive function;
- gender differences;
- sex differences;
- working memory
Objective: Despite evidence that gender may influence neurocognitive functioning, few studies have examined its effects in bipolar disorder (BD) a priori. The aim of this study was to examine how gender influences executive-type functions, which are potentially useful as endophenotypes for BD.
Methods: The performance of 26 euthymic patients (12 males, 14 females) with DSM-IV BD (20 BD type I and six BD type II) was compared to that of 26 controls (12 males, 14 females) on tests of executive function. Controls were matched to patients on an individual basis for sex, age and premorbid IQ. Tests assessed spatial working memory (SWM), planning, attentional set-shifting and verbal fluency.
Results: Overall, patients showed deficits in SWM strategy (p < 0.001) and made more SWM errors relative to controls (p < 0.001). These deficits were more apparent in male-only comparisons (both p < 0.001) than in female-only comparisons (both p < 0.05). When examined in isolation, male controls were significantly better at performing the SWM task than female controls (both p < 0.05). This pattern was not observed in the patient cohort: male patients had poorer strategy scores than female patients (p < 0.05), but made a similar number of SWM errors.
Conclusions: These findings provide evidence that gender can influence the detection of SWM deficits in the euthymic phase of BD, as the sex-related disequilibrium in SWM identified in healthy controls was disrupted in BD.