The authors of this paper do not have any commercial associations that might pose a conflict of interest in connection with this manuscript.
Neuropsychological and electrophysiological indices of neurocognitive dysfunction in bipolar II disorder
Article first published online: 18 NOV 2008
© 2008 The Authors. Journal compilation © 2008 Blackwell Munksgaard
Volume 10, Issue 8, pages 888–899, December 2008
How to Cite
Andersson, S., Barder, H. E., Hellvin, T., Løvdahl, H. and Malt, U. F. (2008), Neuropsychological and electrophysiological indices of neurocognitive dysfunction in bipolar II disorder. Bipolar Disorders, 10: 888–899. doi: 10.1111/j.1399-5618.2008.00638.x
- Issue published online: 18 NOV 2008
- Article first published online: 18 NOV 2008
- Received 2 October 2007, revised and accepted for publication 19 May 2008
- bipolar II disorder;
- event-related potentials;
Objectives: There are conflicting findings regarding the nature and degree of neurocognitive dysfunction in bipolar II disorder (BD II). The aim of this study was to describe different levels of neurocognitive functioning in BD II by combining behavior-based methods (neuropsychological testing) and event-related potentials (ERP).
Methods: Twenty-five consecutively referred outpatients fulfilling DSM-IV criteria for BD II and 28 matched controls performed a neuropsychological test battery targeting working memory/attention, executive functions, verbal and visual memory, and psychomotor speed. In addition, ERPs for measuring early and controlled stages of information processing were recorded using a duration mismatch negativity (MMN) paradigm and a three-tone auditory oddball paradigm.
Results: Compared to controls, BD II patients’ performance was significantly impaired on all neuropsychological measures, except for phonemic verbal fluency, with moderate to strong effect sizes ranging from 0.62 to 1.34. The ERP results indicate dysfunctions in early stages of information processing, showing a significant MMN latency increase and attenuated frontal amplitudes in BD II patients. Female patients showed increased P3a latency compared to female controls, but no group differences were found for P3b latency or amplitude, the ERP component expressing controlled information processing.
Conclusions: The functional significance of neuropsychological impairment is discussed. Differences regarding some aspects of executive function may be related to psychomotor speed, and not primarily to dysexecutive functioning. ERP results must be interpreted with caution, but the differences found in MMN latency and amplitudes may be related to fronto-temporal circuitry underlying pre-attentive stimulus change detection as measured by MMN, and are discussed in relation to previous research on MMN in other neuropsychiatric conditions.