The authors of this paper do not have any commercial associations that might pose a conflict of interest in connection with this manuscript.
Orbitofrontal cortex gray matter volumes in bipolar disorder patients: a region-of-interest MRI study
Article first published online: 25 FEB 2009
© 2009 The Authors. Journal compilation © 2009 Blackwell Munksgaard
Volume 11, Issue 2, pages 145–153, March 2009
How to Cite
Nery, F. G., Chen, H.-H., Hatch, J. P., Nicoletti, M. A., Brambilla, P., Sassi, R. B., Mallinger, A. G., Keshavan, M. S. and Soares, J. C. (2009), Orbitofrontal cortex gray matter volumes in bipolar disorder patients: a region-of-interest MRI study. Bipolar Disorders, 11: 145–153. doi: 10.1111/j.1399-5618.2009.00662.x
- Issue published online: 25 FEB 2009
- Article first published online: 25 FEB 2009
- Received 22 August 2007, revised and accepted for publication 6 June 2008
- bipolar disorder;
- magnetic resonance imaging;
- neuronal plasticity;
- prefrontal cortex;
Objectives: Functional and postmortem studies suggest that the orbitofrontal cortex (OFC) is involved in the pathophysiology of bipolar disorder (BD). This anatomical magnetic resonance imaging (MRI) study examined whether BD patients have smaller OFC gray matter volumes compared to healthy comparison subjects (HC).
Methods: Twenty-eight BD patients were compared to 28 age- and gender-matched HC. Subjects underwent a 1.5T MRI with 3D spoiled gradient recalled acquisition. Total OFC and medial and lateral subdivisions were manually traced by a blinded examiner. Images were segmented and gray matter volumes were calculated using an automated method.
Results: Analysis of covariance, with intracranial volume as covariate, showed that BD patients and HC did not differ in gray matter volumes of total OFC or its subdivisions. However, total OFC gray matter volume was significantly smaller in depressed patients (n = 10) compared to euthymic patients (n = 18). Moreover, total OFC gray matter volumes were inversely correlated with depressive symptom intensity, as assessed by the Hamilton Depression Rating Scale. OFC gray matter volumes were not related to lithium treatment, age at disease onset, number of episodes, or family history of mood disorders.
Conclusions: Our results suggest that abnormal OFC gray matter volumes are not a pervasive characteristic of BD, but may be associated with specific clinical features of the disorder.