The authors of this paper do not have any commercial associations that might pose a conflict of interest in connection with this manuscript.
Structural abnormalities of ventrolateral and orbitofrontal cortex in patients with familial bipolar disorder
Article first published online: 25 FEB 2009
© 2009 The Authors. Journal compilation © 2009 Blackwell Munksgaard
Volume 11, Issue 2, pages 135–144, March 2009
How to Cite
Stanfield, A. C., Moorhead, T. W. J., Job, D. E., McKirdy, J., Sussmann, J. E., Hall, J., Giles, S., Johnstone, E. C., Lawrie, S. M. and McIntosh, A. M. (2009), Structural abnormalities of ventrolateral and orbitofrontal cortex in patients with familial bipolar disorder. Bipolar Disorders, 11: 135–144. doi: 10.1111/j.1399-5618.2009.00666.x
- Issue published online: 25 FEB 2009
- Article first published online: 25 FEB 2009
- Received 31 January 2008, revised and accepted for publication 20 June 2008
- bipolar disorder;
Objectives: Abnormalities of ventral prefrontal function have been widely reported in bipolar disorder, but reports of structural abnormalities in the same region are less consistent. We examined the presence and location of ventral prefrontal abnormalities in a large sample of individuals with bipolar disorder and their relationship to gender, psychotic symptoms, and age.
Methods: Structural magnetic resonance imaging brain scans were carried out on 66 individuals with bipolar disorder, type I, and 66 controls. Voxel-based morphometry was used to examine differences in grey and white matter density between the groups and their relationship with a lifetime occurrence of psychotic symptoms and age.
Results: Reductions in grey matter density were seen in the left and right lateral orbital gyri and the right inferior frontal gyrus, while white matter density reductions were seen in the corona radiata and the left temporal stem. In contrast, hallucinations and positive symptoms were associated with grey matter reduction in the left middle temporal gyrus. Age was more strongly associated with the right inferior frontal gyrus grey matter reductions in the bipolar group than in the controls, but not with any other finding.
Conclusion: Abnormalities of the ventral prefrontal cortex are likely to be involved in the aetiopathology of bipolar disorder, while hallucinations appear to be more closely associated with temporal lobe abnormality, extending earlier work in schizophrenia. Further prospective studies are required to comprehensively address the trajectory of these findings.