These data were presented in part at the 63rd Annual Scientific Meeting and Convention of the Society of Biological Psychiatry, Washington, D.C., USA, May 1–3, 2008.
Sexually dimorphic features of vermis morphology in bipolar disorder
Article first published online: 14 OCT 2009
© 2009 The Authors. Journal compilation © 2009 John Wiley & Sons A/S
Volume 11, Issue 7, pages 753–758, November 2009
How to Cite
Womer, F. Y., Wang, F., Chepenik, L. G., Kalmar, J. H., Spencer, L., Edmiston, E., Pittman, B. P., Constable, R. T., Papademetris, X. and Blumberg, H. P. (2009), Sexually dimorphic features of vermis morphology in bipolar disorder. Bipolar Disorders, 11: 753–758. doi: 10.1111/j.1399-5618.2009.00745.x
HPB has received consultant fees from Pfizer, Inc., and has received honoraria from Abbott Laboratories and Eli Lilly & Co. FYW, FW, LGC, JHK, LS, EE, BPP, RTC and XP have no conflicts of interest to report.
- Issue published online: 14 OCT 2009
- Article first published online: 14 OCT 2009
- Received 5 December 2008, revised and accepted for publication 9 June 2009
- bipolar disorder;
- cerebellar vermis;
- sex difference;
- structural MRI
Objectives: The cerebellar vermis is increasingly implicated in bipolar disorder (BD). In this study, we investigated vermis morphology in BD using a quantitative volumetric analysis.
Methods: Volumes for total vermis and vermis subregions V1 (lobules I–V), V2 (lobules VI–VII), and V3 (lobules VIII–X) were calculated using high-resolution structural magnetic resonance imaging obtained from 44 individuals with BD (25 females and 19 males) and 43 healthy comparison (HC) subjects (26 females and 17 males). Total vermis volumes were compared between the BD and HC groups. Potential effects of vermis subregions and clinical features were explored.
Results: Total vermis volumes were significantly larger in the BD group than in the HC group (p = 0.02). There was a significant group-by-sex interaction (p = 0.02). Total vermis volumes were significantly larger in males with BD than HC males (p = 0.004); vermis volumes did not differ significantly between females with and without BD (p = 0.95). Subregion analyses showed a trend-level interaction between diagnosis and subregion (p = 0.07) in which subregion V1 volumes were significantly larger in BD participants (p = 0.001), with differences primarily driven by males (p = 0.001).
Conclusions: Our findings demonstrate increases in cerebellar vermis volumes in males with BD. These findings support the presence of structural alterations in the cerebellar vermis in BD and furthermore the influence of sex on such changes.