The authors of this paper do not have any commercial associations that might pose a conflict of interest in connection with this manuscript.
Gray matter, white matter, brain, and intracranial volumes in first-episode bipolar disorder: a meta-analysis of magnetic resonance imaging studies
Version of Record online: 16 NOV 2009
© 2009 The Authors. Journal compilation © 2009 John Wiley & Sons A/S
Volume 11, Issue 8, pages 807–814, December 2009
How to Cite
Vita, A., De Peri, L. and Sacchetti, E. (2009), Gray matter, white matter, brain, and intracranial volumes in first-episode bipolar disorder: a meta-analysis of magnetic resonance imaging studies. Bipolar Disorders, 11: 807–814. doi: 10.1111/j.1399-5618.2009.00759.x
- Issue online: 16 NOV 2009
- Version of Record online: 16 NOV 2009
- Received 17 February 2009, revised and accepted for publication 16 July 2009
- bipolar disorder;
- brain morphology;
- first episode;
- magnetic resonance imaging;
Objectives: To perform a comprehensive quantitative analysis of the existing magnetic resonance imaging (MRI) studies of the brain conducted on patients with first-episode bipolar disorder (BD).
Methods: A systematic search was performed of MRI studies that reported quantitative measurements of brain volumes of first-episode bipolar patients and healthy controls. Four meta-analyses were performed for four cerebral regions.
Results: Significant overall effect sizes were demonstrated, with a reduction detected in patients with BD for total intracranial and white matter volumes, but not for gray matter and whole brain volumes.
Conclusions: The available MRI literature indicates that specific structural brain abnormalities are already present in first-episode bipolar patients. These do not overlap with those emerging from previous meta-analyses performed in patients with chronic BD. These findings support the hypothesis of different patterns of changes in brain morphology over the time course of bipolar disorder.