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Keywords:

  • bipolar disorder;
  • dopamine transporter availability;
  • euthymic state;
  • SPECT

Chang TT, Yeh TL, Chiu NT, Chen PS, Huang HY, Yang YK, Lee IH, Lu RB. Higher striatal dopamine transporters in euthymic patients with bipolar disorder: a SPECT study with [99mTc] TRODAT-1. Bipolar Disord 2010: 12: 102–106. © 2010 The Authors. Journal compilation © 2010 John Wiley & Sons A/S.

Objectives:  Dopamine has been implicated in the etiology of bipolar disorder. The aim of this study was to explore striatal dopamine transporter (DAT) availability in euthymic bipolar patients.

Methods:  Seventeen drug-free euthymic bipolar patients were recruited. The availability of DAT was approximated using single photon emission computed tomography (SPECT) with [99mTc] TRODAT-1.

Results:  Compared to the controls, the euthymic bipolar patients had significantly higher availability of striatal DAT.

Conclusions:  Even for patients in the euthymic state, the DAT availability is still higher than that of the controls.