Chang TT, Yeh TL, Chiu NT, Chen PS, Huang HY, Yang YK, Lee IH, Lu RB. Higher striatal dopamine transporters in euthymic patients with bipolar disorder: a SPECT study with [99mTc] TRODAT-1. Bipolar Disord 2010: 12: 102–106. © 2010 The Authors. Journal compilation © 2010 John Wiley & Sons A/S.
Objectives: Dopamine has been implicated in the etiology of bipolar disorder. The aim of this study was to explore striatal dopamine transporter (DAT) availability in euthymic bipolar patients.
Methods: Seventeen drug-free euthymic bipolar patients were recruited. The availability of DAT was approximated using single photon emission computed tomography (SPECT) with [99mTc] TRODAT-1.
Results: Compared to the controls, the euthymic bipolar patients had significantly higher availability of striatal DAT.
Conclusions: Even for patients in the euthymic state, the DAT availability is still higher than that of the controls.